ausblenden:
Schlagwörter:
Dictyostelium discoideum, flow-driven instability, pattern formation
Zusammenfassung:
Dictyostelium discoideum (D.d.) is a valuable model organism to study self-organization and pattern
formation in biology. Recently we reported flow-driven waves in experiments with uniformly
distributed populations of signaling amobae, D.d., and carried out a theoretical study in a onedimensional
model. In this work, we perform two-dimensional numerical simulations using the wellknown
Martiel–Golbeter model to study the effect of the flow profile and intrinsic noise on the flowdriven
waves.Weshow that, in the presence of flow, a persistence noise due to spontaneous cell firing
events can lead to sustained structures that fill the whole length of the system.Wealso show that
external periodic stimuli of cyclic adenosine monophosphate can induce 1:1 and 2:1 entrainments
which are in agreement with our experimental observations.
