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  High-resolution 7T fMRI of human hippocampal subfields during associative learning

Suthana, N. A., Donix, M., Wozny, D. R., Bazih, A., Jones, M., Heidemann, R. M., et al. (2015). High-resolution 7T fMRI of human hippocampal subfields during associative learning. Journal of Cognitive Neuroscience, 27(6), 1194-1206. doi:10.1162/jocn_a_00772.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-7C4C-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-792B-6
Genre: Journal Article

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 Creators:
Suthana, Nanthia A.1, Author
Donix, Markus2, 3, Author
Wozny, David R.4, Author
Bazih, Adam1, Author
Jones, Michael1, Author
Heidemann, Robin M.5, Author              
Trampel, Robert6, Author              
Ekstrom, Arne D.7, Author
Scharf, Maria2, 3, Author
Knowlton, Barbara1, Author
Turner, Robert5, Author              
Bookheimer, Susan Y.1, Author
Affiliations:
1University of California, Los Angeles, CA, USA, ou_persistent22              
2TU Dresden, Germany, ou_persistent22              
3German Center for Neurodegenerative Diseases, Dresden, Germany, ou_persistent22              
4Carnegie Mellon University, Pittsburgh, PA, USA, ou_persistent22              
5Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634550              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
7University of California Davis, CA, USA, ou_persistent22              

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 Abstract: Examining the function of individual human hippocampal subfields remains challenging because of their small sizes and convoluted structures. Previous human fMRI studies at 3 T have successfully detected differences in activation between hippocampal cornu ammonis (CA) field CA1, combined CA2, CA3, and dentate gyrus (DG) region (CA23DG), and the subiculum during associative memory tasks. In this study, we investigated hippocampal subfield activity in healthy participants using an associative memory paradigm during high-resolution fMRI scanning at 7 T. We were able to localize fMRI activity to anterior CA2 and CA3 during learning and to the posterior CA2 field, the CA1, and the posterior subiculum during retrieval of novel associations. These results provide insight into more specific human hippocampal subfield functions underlying learning and memory and a unique opportunity for future investigations of hippocampal subfield function in healthy individuals as well as those suffering from neurodegenerative diseases.

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Language(s): eng - English
 Dates: 2015-04-302015-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1162/jocn_a_00772
PMID: 25514656
PMC: PMC4417053
Other: Epub 2014
 Degree: -

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Title: Journal of Cognitive Neuroscience
Source Genre: Journal
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Publ. Info: Cambridge, MA : MIT Press Journals
Pages: - Volume / Issue: 27 (6) Sequence Number: - Start / End Page: 1194 - 1206 Identifier: ISSN: 0898-929X
CoNE: https://pure.mpg.de/cone/journals/resource/991042752752726