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  Functional cerebral blood volume mapping with simultaneous multi-slice acquisition

Huber, L., Ivanov, D., Guidi, M., Turner, R., Uludag, K., Möller, H. E., et al. (2016). Functional cerebral blood volume mapping with simultaneous multi-slice acquisition. NeuroImage, 125, 1159-1168. doi:10.1016/j.neuroimage.2015.10.082.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-7AE5-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-6543-4
Genre: Journal Article

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 Creators:
Huber, Laurentius1, 2, Author           
Ivanov, Dimo3, Author
Guidi, Maria1, Author           
Turner, Robert4, Author           
Uludag, Kamil3, Author
Möller, Harald E.1, Author                 
Poser, Benedikt A.3, Author
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, USA, ou_persistent22              
3Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
4Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

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Free keywords: Vascular space occupancy; SS-SI VASO; Cerebral blood volume; Simultaneous multi-slice; Multi-band; 7 Tesla MRI
 Abstract: The aim of this study is to overcome the current limits of brain coverage available with multi-slice echo planar imaging (EPI) for vascular space occupancy (VASO) mapping. By incorporating simultaneous multi-slice (SMS) EPI image acquisition into slice-saturation slab-inversion VASO (SS-SI VASO), many more slices can be acquired for non-invasive functional measurements of blood volume responses.

Blood-volume-weighted VASO and gradient echo blood oxygenation level-dependent (GE-BOLD) data were acquired in humans at 7 T with a 32-channel head coil. SMS-VASO was applied in three scenarios: A) high-resolution acquisition of spatially distant brain areas in the visuo-motor network (V1/V5/M1/S1); B) high-resolution acquisition of an imaging slab covering the entire M1/S1 hand regions; and C) low-resolution acquisition with near whole-brain coverage.

The results show that the SMS-VASO sequence provided images enabling robust detection of blood volume changes in up to 20 slices with signal readout durations shorter than 150 ms. High-resolution application of SMS-VASO revealed improved specificity of VASO to GM tissue without contamination from large draining veins compared to GE-BOLD in the visual cortex and in the sensory-motor cortex.

It is concluded that VASO fMRI with SMS-EPI allows obtaining a reasonable three-dimensional coverage not achievable with standard VASO during the short time period when blood magnetization is approximately nulled. Due to the increased brain coverage and better spatial specificity to GM tissue of VASO compared to GE-BOLD signal, the proposed method may play an important role in high-resolution human fMRI at 7 T.

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Language(s): eng - English
 Dates: 2015-07-062015-10-272015-10-302016-01-15
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2015.10.082
PMID: 26522423
Other: Epub 2015
 Degree: -

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Project name : -
Grant ID : VIDI 452-11-002
Funding program : -
Funding organization : Netherlands Organization for Scientific Research NWO
Project name : -
Grant ID : FP7-PEOPLE-2012-ITN-316716
Funding program : Initial Training Network, HiMR - FP7 Marie Curie Actions
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max-Planck-Gesellschaft (MPG)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 125 Sequence Number: - Start / End Page: 1159 - 1168 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166