English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Changes of serotonin transporter (SERT) availability in human obesity prior and 6 month after an integrative treatment approach

Vettermann, F., Rullmann, M., Becker, G., Luthardt, J., Zientek, F., Meyer, P., et al. (2015). Changes of serotonin transporter (SERT) availability in human obesity prior and 6 month after an integrative treatment approach. Journal of Nuclear Medicine, 56(Suppl. 3): 528.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Vettermann, Franziska1, Author
Rullmann, Michael2, Author
Becker, Georg2, Author
Luthardt, Julia2, Author
Zientek, Franziska1, Author
Meyer, Philipp2, Author
Arélin, Katrin3, Author              
Stumvoll, Michael1, Author
Sabri, Osama2, Author
Hesse, Swen2, Author
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              

Content

show
hide
Free keywords: -
 Abstract: Objectives: Central serotonergic systems comprise important neuromodulatory capacity and participate in regulating appetite and satiety, thus contributing to obesogenic mechanism. Especially presynaptic SERT are target structures for modern antidepressants and interventions aiming to reduce weight. The aim of our study was to quantitatively assess SERT availability in obese, non-depressed humans at baseline and following a 6 months integrative treatment program. SERT was compared with changes in body mass index (BMI) as the outcome parameter. This study investigates SERT levels in obese individuals(OB) and normal-weight, healthy control subjects (NW). Methods: Twenty-two OB (BMI 41±5kg/m2, age 38±11yrs, 14♀) and 15 NW (BMI 23±2 kg/m2, age 36±7yrs, 10♀) were investigated prior and after a 6 month of treatment program including diet, physical and psychological intervention by using C-11-DASB and PET. Parametric images of binding potential BPND (MRTM2) were generated from atlas-based analysis of VOI after coregistration with individual 3D MRI data. Results: In OB, BPND and BMI were negatively associated (P<0.05) in the left medial prefrontal cortex (PFC) (R=-0.37), the left dorso-lateral PFC (R=-0.38), the right hippocampus (R=-0.37) and the left amygdala (R=-0.39, p=0.037). All of these regions showed a significant BPND increase after the OB lost weight (delta BMI -1.02±2.1kg/m2). No significant BPND changes over time were found in the NW. Conclusions: Changes of SERT availability in obese are evident in regions thought to be relevant of eating control. Furthermore, correlation between losing weight and higher SERT mainly in the PFC after the 6 month program suggest that the PFC likely has an essential role in feeding behavior modulated by the serotonin system and SERT availability in those brain areas may serve as a predictor for treatment response.

Details

show
hide
Language(s): eng - English
 Dates: 2015-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Nuclear Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Society of Nuclear Medicine
Pages: - Volume / Issue: 56 (Suppl. 3) Sequence Number: 528 Start / End Page: - Identifier: ISSN: 0161-5505
CoNE: https://pure.mpg.de/cone/journals/resource/991042725914954