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  Brain-derived neurotrophic factor and antidepressive effect of electroconvulsive therapy: Systematic review and meta-analyses of the preclinical and clinical literature

Polyakova, M., Schroeter, M. L., Elzinga, B. M., Holiga, Š., Schoenknecht, P., de Kloet, E. R., et al. (2015). Brain-derived neurotrophic factor and antidepressive effect of electroconvulsive therapy: Systematic review and meta-analyses of the preclinical and clinical literature. PLoS One, 10(11): e0141564. doi:10.1371/journal.pone.0141564.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-7E87-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-F3AB-9
Genre: Journal Article

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 Creators:
Polyakova, Maryna1, 2, Author              
Schroeter, Matthias L.1, 3, Author              
Elzinga, B. M.4, Author
Holiga, Štefan3, 5, Author              
Schoenknecht, P.2, Author
de Kloet, E. R.6, Author
Molendijk, M. L.4, Author
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Leiden Institute for Brain and Cognition, Leiden University, the Netherlands, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, the Netherlands, ou_persistent22              

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 Abstract: Emerging data suggest that Electro-Convulsive Treatment (ECT) may reduce depressive symptoms by increasing the expression of Brain-Derived Neurotrophic Factor (BDNF). Yet, conflicting findings have been reported. For this reason we performed a systematic review and meta-analysis of the preclinical and clinical literature on the association between ECT treatment (ECS in animals) and changes in BDNF concentrations and their effect on behavior. In addition, regional brain expression of BDNF in mouse and human brains were compared using Allen Brain Atlas. ECS, over sham, increased BDNF mRNA and protein in animal brain (effect size [Hedge’s g]: 0.38―0.54; 258 effect-size estimates, N = 4,284) but not in serum (g = 0.06, 95% CI = -0.05―0.17). In humans, plasma but not serum BDNF increased following ECT (g = 0.72 vs. g = 0.14; 23 effect sizes, n = 281). The gradient of the BDNF increment in animal brains corresponded to the gradient of the BDNF gene expression according to the Allen brain atlas. Effect-size estimates were larger following more ECT sessions in animals (r = 0.37, P < .0001) and in humans (r = 0.55; P = 0.05). There were some indications that the increase in BDNF expression was associated with behavioral changes in rodents, but not in humans. We conclude that ECS in rodents and ECT in humans increase BDNF concentrations but this is not consistently associated with changes in behavior.

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Language(s): eng - English
 Dates: 2015-04-162015-10-102015-11-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0141564
PMID: 26529101
PMC: PMC4631320
Other: eCollection 2015
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 10 (11) Sequence Number: e0141564 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850