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  Affected connectivity organization of the reward system structure in obesity

Marqués-Iturria, I., Scholtens, L. H., Garolera, M., Pueyo, R., García-García, I., González-Tartiere, P., et al. (2015). Affected connectivity organization of the reward system structure in obesity. NeuroImage, 111, 100-106. doi:10.1016/j.neuroimage.2015.02.012.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-7F78-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-F3DE-0
Genre: Journal Article

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 Creators:
Marqués-Iturria, I.1, 2, Author
Scholtens, L. H.3, Author
Garolera, M.4, 5, Author
Pueyo, R.1, 2, 4, Author
García-García, Isabel1, 6, Author              
González-Tartiere, P.1, Author
Segura, B.1, 4, Author
Junqué, C.1, 4, Author
Sender-Palacios, M. J.7, Author
Vernet-Vernet, M.7, Author
Sánchez-Garre, C.8, Author
de Reus, M. A.3, Author
Juradoa, M. A.1, 2, 4, Author
van den Heuvel, M. P.3, Author
Affiliations:
1Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain, ou_persistent22              
2Institute for Brain, Cognition and Behaviour, Barcelona, Spain, ou_persistent22              
3Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands, ou_persistent22              
4Grup de Recerca Consolidat en Neuropsicologia, Barcelona, Spain, ou_persistent22              
5Neuropsychology Unit, Consorci Sanitari de Terrassa, Barcelona, Spain, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
7CAP Terrassa Nord, Consorci Sanitari de Terrassa, Barcelona, Spain, ou_persistent22              
8Pediatric Endocrinology Unit, Consorci Sanitari de Terrassa, Barcelona, Spain, ou_persistent22              

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Free keywords: Neuroanatomy; Diffusion imaging; Eating; Body mass index; Orbitofrontal cortex; Striatum
 Abstract: With the prevalence of obesity rapidly increasing worldwide, understanding the processes leading to excessive eating behavior becomes increasingly important. Considering the widely recognized crucial role of reward processes in food intake, we examined the white matter wiring and integrity of the anatomical reward network in obesity. Anatomical wiring of the reward network was reconstructed derived from diffusion weighted imaging in 31 obese participants and 32 normal-weight participants. Network wiring was compared in terms of the white matter volume as well as in terms of white matter microstructure, revealing lower number of streamlines and lower fiber integrity within the reward network in obese subjects. Specifically, the orbitofrontal cortex and striatum nuclei including accumbens, caudate and putamen showed lower strength and network clustering in the obesity group as compared to healthy controls. Our results provide evidence for obesity-related disruptions of global and local anatomical connectivity of the reward circuitry in regions that are key in the reinforcing mechanisms of eating-behavior processes.

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Language(s): eng - English
 Dates: 2015-02-082015-02-142015-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2015.02.012
PMID: 25687594
Other: Epub 2015
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 111 Sequence Number: - Start / End Page: 100 - 106 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166