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  Rapid feedback processing in human nucleus accumbens and motor thalamus

Schüller, T., Gruendler, T. O., Jocham, G., Klein, T. A., Timmermann, L., Visser-Vandewalle, V., et al. (2015). Rapid feedback processing in human nucleus accumbens and motor thalamus. Neuropsychologia, 70, 246-254. doi:10.1016/j.neuropsychologia.2015.02.032.

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Schüller, Thomas1, Author
Gruendler, Theo O.J.1, 2, 3, Author
Jocham, Gerhard2, 3, Author
Klein, Tilmann A.4, 5, Author           
Timmermann, Lars6, Author
Visser-Vandewalle, Veerle7, Author
Kuhn, Jens1, Author
Ullsperger, Markus3, 8, 9, Author
1Department of Psychiatry and Psychotherapy, University Hospital Cologne, Germany, ou_persistent22              
2Faculty of Economics and Management, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
3Center for Behavioral Brain Sciences, Magdeburg, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Department of Neurology, University Hospital Cologne, Germany, ou_persistent22              
7Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Germany, ou_persistent22              
8Institute of Psychology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
9Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              


Free keywords: Nucleus accumbens; Thalamus; Feedback-related negativity; Performance monitoring; Deep brain Stimulation; Time estimation task
 Abstract: The nucleus accumbens (NAcc) and thalamus are integral parts in models of feedback processing. Deep brain stimulation (DBS) has been successfully employed to alleviate symptoms of psychiatric conditions including obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS). Common target structures are the NAcc and the ventral anterior and ventro-lateral nuclei (VA/VL) of the thalamus, for OCD and TS, respectively.

The feedback related negativity (FRN) is an event-related potential associated with feedback processing reflecting posterior medial frontal cortex (pMFC) activity. Here we report on three cases where we recorded scalp EEG and local field potentials (LFP) from externalized electrodes located in the NAcc or thalamus (VA/VL) while patients engaged in a modified time estimation task, known to engage feedback processing and elicit the FRN. Additionally, scalp EEG were recorded from 29 healthy participants (HP) engaged in the same task.

The signal in all structures (pMFC, NAcc, and thalamus) was differently modulated by positive and negative feedback. LFP activity in the NAcc showed a biphasic time course after positive feedback during the FRN time interval. Negative feedback elicited a much weaker and later response. In the thalamus a monophasic modulation was recorded during the FRN time interval. Again, this modulation was more pronounced after positive performance feedback compared to negative feedback. In channels outside the target area no modulation was observed. The surface-FRN was reliably elicited on a group level in HP and showed no significant difference following negative feedback between patients and HP.

German Clinical Trial Register: Neurocognitive specification of dysfunctions within basal ganglia-cortex loops and their therapeutic modulation by deep brain stimulation in patients with obsessive compulsive disorder and Tourette syndrome, http://www.drks.de/DRKS00005316.


Language(s): eng - English
 Dates: 2014-11-052015-02-212015-02-262015-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuropsychologia.2015.02.032
PMID: 25726897
Other: Epub 2015
 Degree: -



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Title: Neuropsychologia
Source Genre: Journal
Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 70 Sequence Number: - Start / End Page: 246 - 254 Identifier: ISSN: 0028-3932
CoNE: https://pure.mpg.de/cone/journals/resource/954925428258