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  Sensitivity of rat inferior colliculus neurons to frequency distributions

Herrmann, B., Parthasarathy, A., Han, E. X., Obleser, J., & Bartlett, E. L. (2015). Sensitivity of rat inferior colliculus neurons to frequency distributions. Journal of Neurophysiology, 114(5), 2941-2954. doi:10.1152/jn.00555.2015.

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Genre: Zeitschriftenartikel

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 Urheber:
Herrmann, Björn1, Autor           
Parthasarathy, Aravindakshan2, 3, Autor
Han, Emily X.2, 3, Autor
Obleser, Jonas1, 4, Autor           
Bartlett, Edward L.2, 3, Autor
Affiliations:
1Max Planck Research Group Auditory Cognition, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_751545              
2Department of Biological Sciences, Purdue University, West Lafayette, IN, USA, ou_persistent22              
3Department of Biomedical Engineering, Purdue University, West Lafayette, IN, USA, ou_persistent22              
4Department of Psychology, University of Lübeck, Germany, ou_persistent22              

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Schlagwörter: Inferior colliculus; Stimulus-specific adaptation; Statistical context
 Zusammenfassung: Stimulus-specific adaptation refers to a neural response reduction to a repeated stimulus that does not generalize to other stimuli. However, stimulus-specific adaptation appears to be influenced by additional factors. For example, the statistical distribution of tone frequencies has recently been shown to dynamically alter stimulus-specific adaptation in human auditory cortex. The present study investigated whether statistical stimulus distributions also affect stimulus-specific adaptation at an earlier stage of the auditory hierarchy. Neural spiking activity and local field potentials were recorded from inferior colliculus neurons of rats while tones were presented in oddball sequences that formed two different statistical contexts. Each sequence consisted of a repeatedly presented tone (standard) and three rare deviants of different magnitudes (small, moderate, large spectral change). The critical manipulation was the relative probability with which large spectral changes occurred. In one context the probability was high (relative to all deviants), while it was low in the other context. We observed larger responses for deviants compared with standards, confirming previous reports of increased response adaptation for frequently presented tones. Importantly, the statistical context in which tones were presented strongly modulated stimulus-specific adaptation. Physically and probabilistically identical stimuli (moderate deviants) in the two statistical contexts elicited different response magnitudes consistent with neural gain changes and thus neural sensitivity adjustments induced by the spectral range of a stimulus distribution. The data show that already at the level of the inferior colliculus stimulus-specific adaptation is dynamically altered by the statistical context in which stimuli occur.

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Sprache(n): eng - English
 Datum: 2015-06-052015-09-092015-11-172015-11-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1152/jn.00555.2015
PMID: 26354316
PMC: PMC4737421
Anderer: Epub 2015
 Art des Abschluß: -

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Förderorganisation : Max Planck Society (MPG)
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Grant ID : DC-0011580
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Förderorganisation : NIH National Institute on Deafness & Other Communication Disorders (NIDCD)

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Titel: Journal of Neurophysiology
  Andere : J. Neurophysiol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Bethesda, MD : The Society
Seiten: - Band / Heft: 114 (5) Artikelnummer: - Start- / Endseite: 2941 - 2954 Identifikator: ISSN: 0022-3077
CoNE: https://pure.mpg.de/cone/journals/resource/954925416959