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  BDNF as a biomarker for successful treatment of mood disorders: A systematic & quantitative meta-analysis

Polyakova, M., Stuke, K., Schümberg, K., Mueller, K., Schoenknecht, P., & Schroeter, M. L. (2015). BDNF as a biomarker for successful treatment of mood disorders: A systematic & quantitative meta-analysis. Journal of Affective Disorders, 174, 432-440. doi:10.1016/j.jad.2014.11.044.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-A7BC-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1513-0
Genre: Journal Article

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 Creators:
Polyakova, Maryna1, 2, 3, Author              
Stuke, Katharina1, Author              
Schümberg, Katharina1, Author              
Mueller, Karsten4, Author              
Schoenknecht, Peter2, 3, Author
Schroeter, Matthias L.1, 3, 5, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Brain-derived neurotrophic factor; BDNF; Major depression; Bipolar; Response; Biomarker
 Abstract: Background: Peripheral brain-derived neurotrophic factor (BDNF) is decreased in acute major depressive disorder (MDD) and bipolar disorder (BD) and recovered after treatment. Here we validated on a meta-analytical level whether BDNF restores differentially according to treatment response and whose measurements could be used as a biomarker, plasma or serum. Methods: Using strict inclusion criteria, we compared BDNF in healthy controls and patients with MDD (38 studies, n=6619), and BD (17 studies, n=1447). Pre- and post-treatment BDNF levels were meta-analyzed according to treatment response in patients from 21 MDD studies (n=735) and 7 BD studies (n=88). Serum and plasma subgroups were analyzed, publication bias was assessed and heterogeneity was investigated. Results: Serum and plasma BDNF were decreased in acute MDD and BD, and did not differ in euthymia in comparison with control subjects. Antidepressive treatment increased serum BDNF levels in MDD in responders (Cohen׳s d (d)=1.27, p=4.4E-07) and remitters (d=0.89, p=0.01), significantly more than in non-responders (d=0.11, p=0.69). For plasma BDNF in MDD and for BD, the evidence was insufficient for a meta-analysis. Although no significant difference was found between serum and plasma ES, variance of plasma ES was higher. Limitations: Between-study heterogeneity was explained only partially; signs of publication bias in serum studies. Conclusion: Serum BDNF might be regarded as a biomarker for the successful treatment of MDD. Serum measurements seem more reliable than plasma ones. Further research should focus on defining optimal time points for BDNF measurements and increase evidence for the usage of BDNF as a predictive biomarker in BD.

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Language(s): eng - English
 Dates: 2014-07-282014-11-232014-11-292015-03-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.jad.2014.11.044
PMID: 25553404
Other: Epub 2014
 Degree: -

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Title: Journal of Affective Disorders
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 174 Sequence Number: - Start / End Page: 432 - 440 Identifier: ISSN: 0165-0327
CoNE: /journals/resource/954925480595