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  First evidence for glial pathology in late life minor depression: S100B is increased in males with minor depression

Polyakova, M., Sander, C., Arélin, K., Lampe, L., Luck, T., Luppa, M., et al. (2015). First evidence for glial pathology in late life minor depression: S100B is increased in males with minor depression. Frontiers in Cellular Neuroscience, 9: 406. doi:10.3389/fncel.2015.00406.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-A7D5-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-77A0-2
Genre: Journal Article

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 Creators:
Polyakova, Maryna1, 2, 3, Author              
Sander, Christian2, 3, Author
Arélin, Katrin1, 3, Author              
Lampe, Leonie1, 3, Author              
Luck, Tobias3, 4, Author
Luppa, Melanie3, 4, Author
Kratzsch, Jürgen3, 5, Author
Hoffmann, Karl-Titus6, Author
Riedel-Heller, Steffi3, 4, Author
Villringer, Arno1, 3, 7, Author              
Schoenknecht, Peter2, 3, Author
Schroeter, Matthias L.1, 3, 7, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
5Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
6Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Minor depression; Late life depression; S100B; BDNF; NSE; Glia; White matter hyperintensities; Biomarker
 Abstract: Minor depression is diagnosed when a patient suffers from 2 to 4 depressive symptoms for at least 2 weeks. Though minor depression is a widespread phenomenon, its pathophysiology has hardly been studied. To get a first insight into the pathophysiological mechanisms underlying this disorder we assessed serum levels of biomarkers for plasticity, glial and neuronal function: brain-derived neurotrophic factor (BDNF), S100B and neuron specific enolase (NSE). 27 subjects with minor depressive episode and 82 healthy subjects over 60 years of age were selected from the database of the Leipzig population-based study of civilization diseases (LIFE). Serum levels of BDNF, S100B and NSE were compared between groups, and correlated with age, body-mass index (BMI), and degree of white matter hyperintensities (score on Fazekas scale). S100B was significantly increased in males with minor depression in comparison to healthy males, whereas other biomarkers did not differ between groups (p = 0.10–0.66). NSE correlated with Fazekas score in patients with minor depression (rs = 0.436, p = 0.048) and in the whole sample (rs = 0.252, p = 0.019). S100B correlated with BMI (rs = 0.246, p = 0.031) and with age in healthy subjects (rs = 0.345, p = 0.002). Increased S100B in males with minor depression, without alterations in BDNF and NSE, supports the glial hypothesis of depression. Correlation between white matter hyperintensities and NSE underscores the vascular hypothesis of late life depression.

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Language(s): eng - English
 Dates: 2015-07-312015-09-252015-10-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fncel.2015.00406
PMID: 26500502
PMC: PMC4598479
Other: eCollection 2015
 Degree: -

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Title: Frontiers in Cellular Neuroscience
  Other : Front. Cell. Neurosci.
  Abbreviation : FNCEL
Source Genre: Journal
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Affiliations:
Publ. Info: Frontiers Research Foundation
Pages: - Volume / Issue: 9 Sequence Number: 406 Start / End Page: - Identifier: Other: 1662-5102
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5102