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  Progesterone mediates brain functional connectivity changes during the menstrual cycle: A pilot resting state MRI study

Arélin, K., Mueller, K., Barth, C., Rekkas, P. V., Kratzsch, J., Burmann, I., et al. (2015). Progesterone mediates brain functional connectivity changes during the menstrual cycle: A pilot resting state MRI study. Frontiers in Neuroscience, 9: 44. doi:10.3389/fnins.2015.00044.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-A875-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-78C4-9
Genre: Journal Article

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 Creators:
Arélin, Katrin1, 2, 3, Author              
Mueller, Karsten4, Author              
Barth, Claudia1, Author              
Rekkas, Paraskevi V.5, Author
Kratzsch, Jürgen6, Author
Burmann, Inga1, Author              
Villringer, Arno1, 2, 3, 7, 8, Author              
Sacher, Julia1, 2, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
5Campbell Family Mental Health Research Institute, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
6Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
7Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
8Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Menstrual cycle; RS-fMRI; Functional connectivity; Estradiol; Progesterone
 Abstract: The growing interest in intrinsic brain organization has sparked various innovative approaches to generating comprehensive connectivity-based maps of the human brain. Prior reports point to a sexual dimorphism of the structural and functional human connectome. However, it is uncertain whether subtle changes in sex hormones, as occur during the monthly menstrual cycle, substantially impact the functional architecture of the female brain. Here, we performed eigenvector centrality (EC) mapping in 32 longitudinal resting state fMRI scans of a single healthy subject without oral contraceptive use, across four menstrual cycles, and assessed estrogen and progesterone levels. To investigate associations between cycle-dependent hormones and brain connectivity, we performed correlation analyses between the EC maps and the respective hormone levels. On the whole brain level, we found a significant positive correlation between progesterone and EC in the bilateral dorsolateral prefrontal cortex (DLPFC) and bilateral sensorimotor cortex. In a secondary region-of-interest analysis, we detected a progesterone-modulated increase in functional connectivity of both bilateral DLPFC and bilateral sensorimotor cortex with the hippocampus. Our results suggest that the menstrual cycle substantially impacts intrinsic functional connectivity, particularly in brain areas associated with contextual memory-regulation, such as the hippocampus. These findings are the first to link the subtle hormonal fluctuations that occur during the menstrual cycle, to significant changes in regional functional connectivity in the hippocampus in a longitudinal design, given the limitation of data acquisition in a single subject. Our study demonstrates the feasibility of such a longitudinal Resting-state functional Magnetic Resonance Imaging (rs-fMRI) design and illustrates a means of creating a personalized map of the human brain by integrating potential mediators of brain states, such as menstrual cycle phase.

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Language(s): eng - English
 Dates: 2014-07-252015-02-012015-02-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnins.2015.00044
PMID: 25755630
PMC: PMC4337344
Other: eCollection 2015
 Degree: -

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 9 Sequence Number: 44 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: /journals/resource/1662-4548