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  Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods

Barth, C., Villringer, A., & Sacher, J. (2015). Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods. Frontiers in Neuroscience, 9: 37. doi:10.3389/fnins.2015.00037.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-A87D-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-78AD-4
Genre: Journal Article

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 Creators:
Barth, Claudia1, Author              
Villringer, Arno1, 2, 3, 4, 5, Author              
Sacher, Julia1, 2, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Estrogens; Progesterone; Neurotransmitters; Plasticity; Hormonal transition periods
 Abstract: Sex hormones have been implicated in neurite outgrowth, synaptogenesis, dendritic branching, myelination and other important mechanisms of neural plasticity. Here we review the evidence from animal experiments and human studies reporting interactions between sex hormones and the dominant neurotransmitters, such as serotonin, dopamine, GABA and glutamate. We provide an overview of accumulating data during physiological and pathological conditions and discuss currently conceptualized theories on how sex hormones potentially trigger neuroplasticity changes through these four neurochemical systems. Many brain regions have been demonstrated to express high densities for estrogen- and progesterone receptors, such as the amygdala, the hypothalamus, and the hippocampus. As the hippocampus is of particular relevance in the context of mediating structural plasticity in the adult brain, we put particular emphasis on what evidence could be gathered thus far that links differences in behavior, neurochemical patterns and hippocampal structure to a changing hormonal environment. Finally, we discuss how physiologically occurring hormonal transition periods in humans can be used to model how changes in sex hormones influence functional connectivity, neurotransmission and brain structure in vivo.

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Language(s): eng - English
 Dates: 2014-08-152015-01-262015-02-20
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnins.2015.00037
PMC: PMC4335177
PMID: 25750611
Other: eCollection 2015
 Degree: -

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 9 Sequence Number: 37 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: /journals/resource/1662-4548