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  Cognitive screening in patients with intracranial tumors: Validation of the BCSE

Becker, J., Steinmann, E., Könemann, M., Gabske, S., Mehdorn, H. M., Synowitz, M., et al. (2016). Cognitive screening in patients with intracranial tumors: Validation of the BCSE. Journal of Neuro-Oncology, 127(3), 559-567. doi:10.1007/s11060-016-2064-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-AA56-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1DAC-C
Genre: Journal Article

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 Creators:
Becker, Juliane1, Author
Steinmann, Elisabeth1, Author
Könemann, Maria1, Author
Gabske, Sonja1, Author
Mehdorn, Hubertus Maximilian1, Author
Synowitz, Michael 1, Author
Hartwigsen, Gesa2, 3, Author              
Goebel, Simone1, Author
Affiliations:
1Department of Neurosurgery, University Hospital of Schleswig-Holstein, Kiel, Germany, ou_persistent22              
2Department of Psychology, Christian Albrecht University Kiel, Germany, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Screening instrument; Neuropsychological diagnostic; Intracranial tumor
 Abstract: This study presents the first validation of the Brief Cognitive Status Exam (BCSE) against two other screening tools for cognitive impairment in patients with intracranial tumors. 58 patients and 22 matched healthy controls completed the BCSE, the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Patients were additionally tested with a comprehensive neuropsychological battery. Based on this assessment, they were classified as cognitively impaired or unimpaired on five cognitive domains. Analyses revealed a comparable feasibility of the BCSE relative to the MoCA and the MMSE, but a smaller range of assessed functions (e.g., no correlation with the domain visual-spatial functions). The ability to separate patients and healthy controls was extremely poor for BCSE and MMSE (sensitivity of 38.6 % and less), but moderate for MoCA (sensitivity 68.97 %). Detection of cognitive impairment in patients was worst with BCSE (sensitivity 37 %; MoCA 92.9 %, MMSE 44.4 %) as compared to neuropsychological testing. Moreover, prediction of cognitive outcome was also worst for the BCSE (AUC = .713, NPV = 50 %). An optimal cut-off of 50.5 increased the results slightly. In summary, the BCSE showed good feasibility but no sufficient results in separating healthy individuals from patients or detecting cognitive impairment in patients. Consequently, as a screening measure, we would recommend the MoCA instead of the BCSE. However, since even the MoCA failed to detect cognitive impairment, our study supports the view that reliable results could only be obtained with a comprehensive neuropsychological battery.

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Language(s): eng - English
 Dates: 2015-09-162016-01-222016-02-012016-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s11060-016-2064-6
PMID: 26830092
Other: Epub 2016
 Degree: -

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Title: Journal of Neuro-Oncology
  Other : J. Neuro-Oncol.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 127 (3) Sequence Number: - Start / End Page: 559 - 567 Identifier: ISSN: 0167-594X
CoNE: /journals/resource/954925483657