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  Differential cerebral response to somatosensory stimulation of an acupuncture point vs. two non-acupuncture points measured with EEG and fMRI

Nierhaus, T., Pach, D., Huang, W., Long, X., Napadow, V., Roll, S., et al. (2015). Differential cerebral response to somatosensory stimulation of an acupuncture point vs. two non-acupuncture points measured with EEG and fMRI. Frontiers in Human Neuroscience, 9: 74. doi:10.3389/fnhum.2015.00074.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-A9FE-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-78C0-D
Genre: Journal Article

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 Creators:
Nierhaus, Till1, 2, Author              
Pach, Daniel2, Author
Huang, Wenjing3, 4, Author
Long, Xiangyu2, Author              
Napadow, Vitaly5, 6, Author
Roll, Stephanie3, Author
Liang, Fanrong4, Author
Pleger, Burkhard2, Author              
Villringer, Arno1, 2, Author              
Witt, Claudia M.3, 7, Author
Affiliations:
1Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
4Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, China, ou_persistent22              
5Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA, ou_persistent22              
6Department of Radiology, Logan College of Chiropractic, Chesterfield, MO, USA, ou_persistent22              
7Institute for Complementary and Integrative Medicine, University Hospital Zurich, Switzerland, ou_persistent22              

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Free keywords: Somatosensory stimulation; Functional magnetic resonance imaging (fMRI); Electroencephalography (EEG); Acupuncture; Background rhythm; Functional connectivity
 Abstract: Acupuncture can be regarded as a complex somatosensory stimulation. Here, we evaluate whether the point locations chosen for a somatosensory stimulation with acupuncture needles differently change the brain activity in healthy volunteers. We used EEG, event-related fMRI, and resting-state functional connectivity fMRI to assess neural responses to standardized needle stimulation of the acupuncture point ST36 (lower leg) and two control point locations (CP1 same dermatome, CP2 different dermatome). Cerebral responses were expected to differ for stimulation in two different dermatomes (CP2 different from ST36 and CP1), or stimulation at the acupuncture point vs. the control points. For EEG, mu rhythm power increased for ST36 compared to CP1 or CP2, but not when comparing the two control points. The fMRI analysis found more pronounced insula and S2 (secondary somatosensory cortex) activation, as well as precuneus deactivation during ST36 stimulation. The S2 seed-based functional connectivity analysis revealed increased connectivity to right precuneus for both comparisons, ST36 vs. CP1 and ST36 vs. CP2, however in different regions. Our results suggest that stimulation at acupuncture points may modulate somatosensory and saliency processing regions more readily than stimulation at non-acupuncture point locations. Also, our findings suggest potential modulation of pain perception due to acupuncture stimulation.

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Language(s): eng - English
 Dates: 2014-07-252015-01-292015-02-13
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnhum.2015.00074
PMID: 25741269
PMC: PMC4327308
Other: eCollection 2015
 Degree: -

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 9 Sequence Number: 74 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: /journals/resource/1662-5161