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Abstract:
Cryoelectron tomography allows 3D imaging of crowded pleiomorphic environments at molecular resolution and is consequently an excellent method for studying the structure and organization of large molecules in their natural context. Using this approach for the analysis of ribosomal complexes in different cellular compartments, we obtained detailed insights into the supramolecular organization of the cytosolic and mitochondrial translation machineries and their association to membranes for co-translational protein transport.
