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  The GroEL-GroES Chaperonin Machine: A Nano-Cage for Protein Folding

Hayer-Hartl, M., Bracher, A., & Hartl, F. U. (2016). The GroEL-GroES Chaperonin Machine: A Nano-Cage for Protein Folding. Trends in Biochemical Sciences: TIBS / International Union of Biochemistry and Molecular Biology., 41(1; Special Issue: 40 Years of TiBS), 62-76. doi:10.1016/j.tibs.2015.07.009.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-AD12-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-AD13-1
Genre: Journal Article

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 Creators:
Hayer-Hartl, Manajit1, 2, Author              
Bracher, Andreas2, Author              
Hartl, F. Ulrich2, Author              
Affiliations:
1Hayer-Hartl, Manajit / Chaperonin-assisted Protein Folding, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565153              
2Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              

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Free keywords: ESCHERICHIA-COLI; IN-VIVO; SUBSTRATE PROTEIN; MASS-SPECTROMETRY; REACTION CYCLE; E. COLI; CONFORMATIONAL-CHANGES; MOLECULAR CHAPERONES; FUNCTIONAL FORM; COMPLEX
 Abstract: The bacterial chaperonin GroEL and its cofactor GroES constitute the paradigmatic molecular machine of protein folding. GroEL is a large double-ring cylinder with ATPase activity that binds non-native substrate protein (SP) via hydrophobic residues exposed towards the ring center. Binding of the lid-shaped GroES to GroEL displaces the bound protein into an enlarged chamber, allowing folding to occur unimpaired by aggregation. GroES and SP undergo cycles of binding and release, regulated allosterically by the GroEL ATPase. Recent structural and functional studies are providing insights into how the physical environment of the chaperonin cage actively promotes protein folding, in addition to preventing aggregation. Here, we review different models of chaperonin action and discuss issues of current debate.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Trends in Biochemical Sciences : TIBS / International Union of Biochemistry and Molecular Biology.
  Other : TRENDS BIOCHEM SCI
Source Genre: Journal
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Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: 41 (1; Special Issue: 40 Years of TiBS) Sequence Number: - Start / End Page: 62 - 76 Identifier: ISSN: 0376-5067
CoNE: https://pure.mpg.de/cone/journals/resource/954925582191