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  Mortality in individuals with subjective cognitive decline: Results of the Leipzig Longitudinal Study of the Aged (LEILA75+)

Luck, T., Roehr, S., Jessen, F., Villringer, A., Angermeyer, M. C., & Riedel-Heller, S. G. (2015). Mortality in individuals with subjective cognitive decline: Results of the Leipzig Longitudinal Study of the Aged (LEILA75+). Journal of Alzheimer's Disease, 48(Suppl. 1), S33-S42. doi:10.3233/JAD-150090.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-ACA8-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-796E-B
Genre: Journal Article


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Luck, Tobias1, 2, Author
Roehr, Susanne1, Author
Jessen, Frank3, 4, Author
Villringer, Arno5, 6, Author              
Angermeyer, Matthias C.7, 8, Author
Riedel-Heller, Steffi G.1, Author
1Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Department of Psychiatry and Psychotherapy, University Hospital Cologne, Germany, ou_persistent22              
4German Center for Neurodegenerative Diseases, Bonn, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
7Center for Public Mental Health, Goesing a. W., Austria, ou_persistent22              
8Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Italy, ou_persistent22              


Free keywords: Dementia; Epidemiology; Mortality; Subjective cognitive decline
 Abstract: Background: Studies have shown that dementia and cognitive impairment can increase mortality, but less is known about the association between subjectively perceived cognitive deficits (subjective cognitive decline, SCD) and mortality risk. Objective: In this study, we analyzed mortality in non-demented individuals with SCD in a general population sample aged 75+ years. Method: Data were derived from the Leipzig Longitudinal Study of the Aged (LEILA75+). We used the Kaplan-Meier survival method to estimate survival times of individuals with and without SCD and multivariable Cox proportional hazards regression to assess the association between SCD and mortality risk, controlled for covariates. Results: Out of 953 non-demented individuals at baseline, 117 (12.3% ) expressed SCD. Participants with SCD showed a significantly higher case-fatality rate per 1,000 person-years (114.8, 95% CI = 90.5–145.7 versus 71.7, 95% CI = 64.6–79.5) and a significantly shorter mean survival time than those without (5.4 versus 6.9 years, p <  0.001). The association between SCD and mortality remained significant in the Cox analysis; SCD increased mortality risk by about 50% (adjusted Hazard Ratio = 1.51) during the study period. Besides SCD, older age, male gender, diabetes mellitus, stroke, and lower global cognitive functioning were also significantly associated with increased mortality. Conclusion: Our findings suggest an increased mortality risk in non-demented older individuals with SCD. Even though further studies are required to analyze potential underlying mechanisms, subjective reports on cognitive deficits may be taken seriously in clinical practice not only for an increased risk of developing dementia and AD but also for a broader range of possible adverse health outcomes.


Language(s): eng - English
 Dates: 2015-05-152015-09-242015
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3233/JAD-150090
PMID: 26402077
 Degree: -



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Title: Journal of Alzheimer's Disease
  Abbreviation : J. Alzheimers Dis.
Source Genre: Journal
Publ. Info: Amsterdam : IOS Press
Pages: - Volume / Issue: 48 (Suppl. 1) Sequence Number: - Start / End Page: S33 - S42 Identifier: ISSN: 1387-2877
CoNE: https://pure.mpg.de/cone/journals/resource/1387-2877