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  Alzheimer’s disease FDG PET imaging pattern in an amyloid-negative mild cognitive impairment subject

Tiepolt, S., Patt, M., Hoffmann, K.-T., Schroeter, M. L., Sabri, O., & Barthel, H. (2015). Alzheimer’s disease FDG PET imaging pattern in an amyloid-negative mild cognitive impairment subject. Journal of Alzheimer's Disease, 47(3), 539-543. doi:10.3233/JAD-150163.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-ACB8-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-7994-E
Genre: Journal Article

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 Creators:
Tiepolt, Solveig1, Author
Patt, Marianne1, Author
Hoffmann, Karl-Titus2, Author
Schroeter, Matthias L.3, 4, 5, Author           
Sabri, Osama1, 5, Author
Barthel, Henryk1, Author
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              

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Free keywords: Alzheimer’s disease; Amyloid; FDG; Mild cognitive impairment; PET
 Abstract: The revised NIA-AA diagnostic criteria for Alzheimer’s disease (AD) and mild cognitive impairment (MCI) due to AD make use of amyloid pathology and neurodegeneration biomarkers which increase the diagnostic confidence in the majority of patients. However, in daily praxis, cases with conflicting biomarker constellations occur. A MCI subject underwent neuropsychological testing supplemented by FDG and amyloid PET/MRI as well as CSF sampling. In this subject, the biomarkers of Aβ deposition were negative. [18F]FDG PET, however, showed an AD-typical hypometabolism. Further studies are required to determine frequency and relevance of cases with neurodegeneration-first biomarker constellations to improve our understanding on pathogenesis and diagnosis of AD.

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Language(s): eng - English
 Dates: 2015-05-092015-08-032015
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3233/JAD-150163
PMID: 26401690
 Degree: -

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Title: Journal of Alzheimer's Disease
  Abbreviation : J. Alzheimers Dis.
Source Genre: Journal
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Affiliations:
Publ. Info: Amsterdam : IOS Press
Pages: - Volume / Issue: 47 (3) Sequence Number: - Start / End Page: 539 - 543 Identifier: ISSN: 1387-2877
CoNE: https://pure.mpg.de/cone/journals/resource/1387-2877