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  Potential determinants of efficacy of mirror therapy in stroke patients: A pilot study

Brunetti, M., Morkisch, N., Fritzsch, C., Mehnert, J., Steinbrink, J., Niedeggen, M., et al. (2015). Potential determinants of efficacy of mirror therapy in stroke patients: A pilot study. Restorative Neurology and Neuroscience, 33(4), 421-434. doi:10.3233/RNN-140421.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-ACFB-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7767-4
Genre: Journal Article

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Brunetti_Morkisch_2015.pdf (Publisher version), 188KB
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 Creators:
Brunetti, Maddalena1, 2, 3, Author
Morkisch, Nadine1, 3, Author
Fritzsch, Clairea1, 3, Author
Mehnert, Jan4, 5, 6, Author              
Steinbrink, Jens3, 4, Author
Niedeggen, Michael2, Author
Dohle, Christian1, 3, Author
Affiliations:
1Median Clinic Berlin-Kladow, Germany, ou_persistent22              
2Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
3Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
4Berlin Center for Advanced Neuroimaging (BCAN), Charité University Medicine Berlin, Germany, ou_persistent22              
5Department of Machine Learning, TU Berlin, Germany, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              

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Free keywords: Mirror therapy; Stroke; Motor recovery; fNIRS; Precuneus
 Abstract: Background: Mirror therapy (MT) was found to improve motor function after stroke. However, there is high variability between patients regarding motor recovery. Objectives: The following pilot study was designed to identify potential factors determining this variability between patients with severe upper limb paresis, receiving MT. Methods: Eleven sub-acute stroke patients with severe upper limb paresis participated, receiving in-patient rehabilitation. After a set of pre-assessments (including measurement of brain activity at the primary motor cortex and precuneus during the mirror illusion, using near-infrared spectroscopy as described previously), four weeks of MT were applied, followed by a set of post-assessments. Discriminant group analysis for MT responders and non-responders was performed. Results: Six out of eleven patients were defined as responders and five as non-responders on the basis of their functional motor improvement. The initial motor function and the activity shift in both precunei (mirror index) were found to discriminate significantly between responders and non-responders. Conclusions: In line with earlier results, initial motor function was confirmed as crucial determinant of motor recovery. Additionally, activity response to the mirror illusion in both precunei was found to be a candidate for determination of the efficacy of MT.

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Language(s): eng - English
 Dates: 2015-08-19
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3233/RNN-140421
PMID: 26409402
PMC: PMC4923713
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Title: Restorative Neurology and Neuroscience
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier Science Publishers BV
Pages: - Volume / Issue: 33 (4) Sequence Number: - Start / End Page: 421 - 434 Identifier: ISSN: 0922-6028
CoNE: /journals/resource/954925565698