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  Can rhythmic auditory cuing remediate language-related deficits in Parkinson's disease?

Kotz, S. A., & Gunter, T. C. (2015). Can rhythmic auditory cuing remediate language-related deficits in Parkinson's disease? Annals of the New York Academy of Sciences, 1337, 62-68. doi:10.1111/nyas.12657.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-ADA2-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-798B-9
Genre: Journal Article

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 Creators:
Kotz, Sonja A.1, 2, Author              
Gunter, Thomas C.2, Author              
Affiliations:
1School of Psychological Sciences, University of Manchester, United Kingdom, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Auditory cuing; Rhythm; Speech and language; Remediation; Parkinson's disease; ERP
 Abstract: Neurodegenerative changes of the basal ganglia in idiopathic Parkinson's disease (IPD) lead to motor deficits as well as general cognitive decline. Given these impairments, the question arises as to whether motor and nonmotor deficits can be ameliorated similarly. We reason that a domain-general sensorimotor circuit involved in temporal processing may support the remediation of such deficits. Following findings that auditory cuing benefits gait kinematics, we explored whether reported language-processing deficits in IPD can also be remediated via auditory cuing. During continuous EEG measurement, an individual diagnosed with IPD heard two types of temporally predictable but metrically different auditory beat-based cues: a march, which metrically aligned with the speech accent structure, a waltz that did not metrically align, or no cue before listening to naturally spoken sentences that were either grammatically well formed or were semantically or syntactically incorrect. Results confirmed that only the cuing with a march led to improved computation of syntactic and semantic information. We infer that a marching rhythm may lead to a stronger engagement of the cerebello–thalamo–cortical circuit that compensates dysfunctional striato–cortical timing. Reinforcing temporal realignment, in turn, may lead to the timely processing of linguistic information embedded in the temporally variable speech signal.

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Language(s): eng - English
 Dates: 2015-03-132015-03-13
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1111/nyas.12657
PMID: 25773618
 Degree: -

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Title: Annals of the New York Academy of Sciences
  Other : Ann. N.Y. Acad. Sci.
Source Genre: Journal
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Publ. Info: New York : New York Academy of Sciences
Pages: - Volume / Issue: 1337 Sequence Number: - Start / End Page: 62 - 68 Identifier: ISSN: 0077-8923
CoNE: /journals/resource/954926958894_2