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  A vocabulary of ancient peptides at the origin of folded proteins.

Alva, V., Söding, J., & Lupas, A. N. (2015). A vocabulary of ancient peptides at the origin of folded proteins. eLife, 4: e09410. doi:10.7554/eLife.09410.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-B088-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6D9F-9
Genre: Journal Article

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Alva, V., Author
Söding, J.1, Author              
Lupas, A. N., Author
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1Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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 Abstract: The seemingly limitless diversity of proteins in nature arose from only a few thousand domain prototypes, but the origin of these themselves has remained unclear. We are pursuing the hypothesis that they arose by fusion and accretion from an ancestral set of peptides active as co-factors in RNA-dependent replication and catalysis. Should this be true, contemporary domains may still contain vestiges of such peptides, which could be reconstructed by a comparative approach in the same way in which ancient vocabularies have been reconstructed by the comparative study of modern languages. To test this, we compared domains representative of known folds and identified 40 fragments whose similarity is indicative of common descent, yet which occur in domains currently not thought to be homologous. These fragments are widespread in the most ancient folds and enriched for iron-sulfur- and nucleic acid-binding. We propose that they represent the observable remnants of a primordial RNA-peptide world.

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Language(s): eng - English
 Dates: 2015-12-14
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.7554/eLife.09410.001
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Title: eLife
Source Genre: Journal
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Pages: 19 Volume / Issue: 4 Sequence Number: e09410 Start / End Page: - Identifier: -