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  Novel Topography of the Rab11-Effector Interaction Network Within a Ciliary Membrane Targeting Complex

Vetter, M., Wang, J., Lorentzen, E., & Deretic, D. (2015). Novel Topography of the Rab11-Effector Interaction Network Within a Ciliary Membrane Targeting Complex. Small GTPases, 6(4), 165-173. doi:10.1080/21541248.2015.1091539.

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 Creators:
Vetter, Melanie1, Author              
Wang, Jing, Author
Lorentzen, Esben1, Author              
Deretic, Dusanka, Author
Affiliations:
1Lorentzen, Esben / Intraflagellar Transport, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565157              

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Free keywords: Rab GTPases, GTPase effectors, Golgi, cilium, membrane trafficking
 Abstract: Small GTPases function as universal molecular switches due to the nucleotide dependent conformational changes of their switch regions that allow interacting proteins to discriminate between the active GTP-bound and the inactive GDP-bound states. Guanine nucleotide exchange factors (GEFs) recognize the inactive GDP-bound conformation whereas GTPase activating proteins (GAPs), and the GTPase effectors recognize the active GTP-bound state. Small GTPases are linked to each other through regulatory and effector proteins into functional networks that regulate intracellular membrane traffic through diverse mechanisms that include GEF and GAP cascades, GEF-effector interactions, common effectors and positive feedback loops linking interacting proteins. As more structural and functional information is becoming available, new types of interactions between regulatory proteins, and new mechanisms by which GTPases are networked to control membrane traffic are being revealed. This review will focus on the structure and function of the novel Rab11-FIP3-Rabin8 dual effector complex and its implications for the targeting of sensory receptors to primary cilia, dysfunction of which causes cilia defects underlying human diseases and disorders know as ciliopathies.

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Language(s): eng - English
 Dates: 2015-09-23
 Publication Status: Published online
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1080/21541248.2015.1091539
 Degree: -

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Title: Small GTPases
Source Genre: Journal
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Publ. Info: Oxford : Taylor & Francis Online
Pages: - Volume / Issue: 6 (4) Sequence Number: - Start / End Page: 165 - 173 Identifier: ISSN: 2154-1256