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  Self-replication of information-bearing nanoscale patterns

Wang, T., Sha, R., Dreyfus, R., Leunissen, M. E., Maass, C. C., Pine, D. J., et al. (2011). Self-replication of information-bearing nanoscale patterns. Nature, 478, 225-228. doi:10.1038/nature10500.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-B44B-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-B44C-0
Genre: Journal Article

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 Creators:
Wang, Tong, Author
Sha, Ruojie, Author
Dreyfus, Rémi, Author
Leunissen, Mirjam E., Author
Maass, Corinna C.1, Author              
Pine, David J., Author
Chaikin, Paul M., Author
Seeman, Nadrian C., Author
Affiliations:
1Group Active soft matter, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063307              

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 Abstract: DNA molecules provide what is probably the most iconic example of self-replication—the ability of a system to replicate, or make copies of, itself. In living cells the process is mediated by enzymes and occurs autonomously, with the number of replicas increasing exponentially over time without the need for external manipulation. Self-replication has also been implemented with synthetic systems, including RNA enzymes designed to undergo self-sustained exponential amplification1, 2, 3, 4, 5. An exciting next step would be to use self-replication in materials fabrication, which requires robust and general systems capable of copying and amplifying functional materials or structures. Here we report a first development in this direction, using DNA tile motifs that can recognize and bind complementary tiles in a pre-programmed fashion. We first design tile motifs so they form a seven-tile seed sequence; then use the seeds to instruct the formation of a first generation of complementary seven-tile daughter sequences; and finally use the daughters to instruct the formation of seven-tile granddaughter sequences that are identical to the initial seed sequences. Considering that DNA is a functional material that can organize itself and other molecules into useful structures6, 7, 8, 9, 10, 11, 12, 13, our findings raise the tantalizing prospect that we may one day be able to realize self-replicating materials with various patterns or useful functions.

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Language(s): eng - English
 Dates: 2011-10-122011-10-13
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/nature10500
BibTex Citekey: wang_self-replication_2011
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Title: Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 478 Sequence Number: - Start / End Page: 225 - 228 Identifier: ISSN: 0028-0836
CoNE: /journals/resource/954925427238