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  Aneuploidy and proteotoxic stress in cancer

Donnelly, N., & Storchova, Z. (2015). Aneuploidy and proteotoxic stress in cancer. Molecular & Cellular Oncology, 2(2): e976491. doi:10.4161/23723556.2014.976491.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-B416-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-B417-6
Genre: Journal Article

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 Creators:
Donnelly, Neysan1, Author           
Storchova, Zuzana1, Author           
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1Storchova, Zuzana / Maintenance of Genome Stability, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565171              

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Free keywords: aneuploidy, cancer, HSF1, HSP90, proteotoxic stress
 Abstract: Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuploidy and proteotoxic stress. Further, our fi ndings implicate HSF1 as a key factor in mitigating the effects of aneuploidy

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published online
 Pages: 2
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.4161/23723556.2014.976491
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Title: Molecular & Cellular Oncology
Source Genre: Journal
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Publ. Info: Oxford : Taylor & Francis
Pages: - Volume / Issue: 2 (2) Sequence Number: e976491 Start / End Page: - Identifier: ISSN: 2372-355