ausblenden:
Schlagwörter:
aneuploidy, cancer, HSF1, HSP90, proteotoxic stress
Zusammenfassung:
Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently
demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function,
suggesting a functional link between two recurring features of cancer cells: aneuploidy and proteotoxic stress. Further,
our
fi
ndings implicate HSF1 as a key factor in mitigating the effects of aneuploidy
