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  A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A

Jensen, V., Kaiser, K., Borchardt, T., Adelmann, G., Rozov, A., Burnashev, N., et al. (2003). A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A. The Journal of Physiology - London, 553(3), 843-856. doi:10.1113/jphysiol.2003.053637.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-B992-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-B993-2
Genre: Journal Article
Alternative Title : A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A

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 Creators:
Jensen, Vidar, Author
Kaiser, Katharina1, Author              
Borchardt, Thilo2, Author              
Adelmann, Giselind, Author
Rozov, Andrej1, 2, Author              
Burnashev, Nail1, Author              
Brix, Christian, Author
Frotscher, Michael, Author
Andersen, Per, Author
Hvalby, Øyvind, Author
Sakmann, Bert1, Author              
Seeburg, Peter H.2, Author              
Sprengel, Rolf2, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: In adult mice, long-term potentiation (LTP) of synaptic transmission at CA3-to-CA1 synapses induced by tetanic stimulation requires L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors containing GluR-A subunits. Here, we report a GluR-A-independent form of LTP, which is comparable in size to LTP in wild-type mice at postnatal day 14 (P14) but diminishes between P14 and P42 in brain slices of GluR-A-deficient mice. The GluR-A-independent form of LTP is sensitive to D(-)-2-amino-5-phosphonopentanoic acid (D-AP5), but lacks short-term potentiation (STP) and can also be observed in the pairing induction protocol. As judged by unaltered paired-pulse facilitation, this LTP form is postsynaptically expressed despite depleted extrasynaptic AMPA receptor pools with reduced levels of GluR-B, which accumulates in somata and synapses of CA1 pyramidal neurons in GluR-A-deficient mice. Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit.

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Language(s): eng - English
 Dates: 2003-08-192003-10-082003-10-102003-12-15
 Publication Status: Published in print
 Pages: 14
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 Rev. Method: Peer
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Title: The Journal of Physiology - London
Source Genre: Journal
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Publ. Info: London : Cambridge University Press
Pages: - Volume / Issue: 553 (3) Sequence Number: - Start / End Page: 843 - 856 Identifier: ISSN: 0022-3751
CoNE: https://pure.mpg.de/cone/journals/resource/954925334693_2