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  The turnover of strains in intermittent and persistent nasal carriers of Staphylococcus aureus

Ritchie, S. R., Isdale, E., Priest, P., Rainey, P. B., & Thomas, M. G. (2016). The turnover of strains in intermittent and persistent nasal carriers of Staphylococcus aureus. The Journal of Infection, 72(3), 295-301. doi:10.1016/j.jinf.2015.12.010.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-C355-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-204F-6
Genre: Journal Article

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Ritchie_et_al_2016.pdf (Publisher version), 653KB
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 Creators:
Ritchie, S. R., Author
Isdale, E., Author
Priest, P., Author
Rainey, P. B.1, Author              
Thomas, M. G., Author
Affiliations:
1External Scientific Member Group Experimental and Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445637              

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Free keywords: Carriage; Dynamics; Healthy adults; spa typing; Staphylococcus aureus; Transmission
 Abstract: OBJECTIVES: We aimed to examine the dynamics of Staphylococcus aureus nasal carriage in healthy adults. METHOD: Selected S. aureus strains isolated from weekly nasal swabs obtained from 122 healthy young adults over a 13 week period were spa typed. RESULTS: The median duration of intermittent carriage was 4 weeks (IQR 2-6) and the median interval between episodes of carriage of different spa types was 3.5 weeks (IQR 2.25-4). 6/19 (32%) Persistent carriers were colonised with more than one spa type during the study, and in two persistent carriers a brief period of mixed colonisation with two spa types was observed. Even when the carriage strain changed, it was very rare for persistent carriers to have a period during which they were culture-negative (only 6/188 (3%) swabs submitted by persistent carriers failed to culture S. aureus). CONCLUSIONS: Our results imply that at least every eight weeks a healthy young adult is exposed to S. aureus sufficient to cause a new episode of carriage among intermittent carriers. Persistent carriers are almost always colonised with S. aureus and over the course of a year there will be at least one replacement of the dominant strain.

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Language(s): eng - English
 Dates: 2015-11-202015-12-242016-03
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1016/j.jinf.2015.12.010
BibTex Citekey: ritchie_turnover_2016
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Project name : -
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Funding program : Allan Wilson Centre
Funding organization : Health Research Council of New Zealand

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Title: The Journal of Infection
Source Genre: Journal
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Pages: - Volume / Issue: 72 (3) Sequence Number: - Start / End Page: 295 - 301 Identifier: ISSN: 1532-2742