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  A common variant of the CNTNAP2 gene is associated with structural variation in the left superior occipital gyrus

Udden, J., Snijders, T. M., Fisher, S. E., & Hagoort, P. (2017). A common variant of the CNTNAP2 gene is associated with structural variation in the left superior occipital gyrus. Brain and Language, 172, 16-21. doi:10.1016/j.bandl.2016.02.003.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-BDD8-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-A2BA-0
Genre: Journal Article

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 Creators:
Udden, Julia1, 2, Author           
Snijders, Tineke M.2, 3, Author           
Fisher, Simon E.2, 4, Author           
Hagoort, Peter1, 2, Author           
Affiliations:
1Neurobiology of Language Department, MPI for Psycholinguistics, Max Planck Society, ou_792551              
2Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
3Center for Language Studies, External Organization, ou_55238              
4Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              

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 Abstract: The CNTNAP2 gene encodes a cell-adhesion molecule that influences the properties of neural networks and the morphology and density of neurons and glial cells. Previous studies have shown association of CNTNAP2 variants with language-related phenotypes in health and disease. Here, we report associations of a common CNTNAP2 polymorphism (rs7794745) with variation in grey matter in a region in the dorsal visual stream. We tried to replicate an earlier study on 314 subjects by Tan and colleagues (2010), but now in a substantially larger group of more than 1700 subjects. Carriers of the T allele showed reduced grey matter volume in left superior occipital gyrus, while we did not replicate associations with grey matter volume in other regions identified by Tan et al (2010). Our work illustrates the importance of independent replication in neuroimaging genetic studies of language-related candidate genes.

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Language(s): eng - English
 Dates: 201620162017
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.bandl.2016.02.003
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Title: Brain and Language
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 172 Sequence Number: - Start / End Page: 16 - 21 Identifier: ISSN: 0093-934X
CoNE: https://pure.mpg.de/cone/journals/resource/954922647078