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  A common architecture for K+ channels and ionotropic glutamate receptors?

Kuner, T., Seeburg, P. H., & Guy, H. R. (2003). A common architecture for K+ channels and ionotropic glutamate receptors? Trends in Neurosciences, 26(1), 27-32. doi:10.1016/S0166-2236(02)00010-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-C3BF-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-C3C0-F
Genre: Journal Article
Alternative Title : A common architecture for K+ channels and ionotropic glutamate receptors?

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TiNS_26_2003_27.pdf (Any fulltext), 364KB
 
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 Creators:
Kuner, Thomas1, 2, Author              
Seeburg, Peter H.1, Author              
Guy, H. Robert, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: K+ channels and ionotropic glutamate receptors are thought to share a common architecture in their transmembrane pores. This oft-cited hypothesis has been derived from sequence comparisons, topology profiling and analogies to a bacterial glutamate receptor with a K+-channel pore. Although none of these arguments provides sufficient evidence for structural kinship, existing structural data and a new pedigree of bacterial glutamate receptors offer strong support. Comparisons of the patterns of pore-lining residues and mapping of functional determinants reveal extensive structural similarities, and new homologs of bacterial glutamate receptors strengthen the evolutionary link between glutamate receptors and K+ channels.

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Language(s): eng - English
 Dates: 2003-12-042003-01-01
 Publication Status: Published in print
 Pages: 6
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 Table of Contents: -
 Rev. Method: Peer
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Title: Trends in Neurosciences
  Other : Trends Neurosci.
Source Genre: Journal
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Publ. Info: Oxford : Elsevier Current Trends
Pages: - Volume / Issue: 26 (1) Sequence Number: - Start / End Page: 27 - 32 Identifier: ISSN: 0166-2236
CoNE: https://pure.mpg.de/cone/journals/resource/954927741850