Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal 
Circuitry and Its Role in Vision

Cao, Yan; Sarria, Ignacio; Fehlhaber, Katherine E.; Kamasawa, Naomi; Orlandi, Cesare; James, Kiely N.; Hazen, Jennifer L.; Gardner, Matthew R.; Farzan, Michael; Lee, Amy; Baker, Sheila; Baldwin, Kristin; Sampath, Alapakkam P.; Martemyanov, Kirill A.

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Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision

Cao, Y., Sarria, I., Fehlhaber, K., Kamasawa, N., Orlandi, C., James, K., et al. (2015). Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision. Neuron, 87(6), 1248-1260.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-C795-D Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-C7BB-8

Genre: Journal Article

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http://dx.doi.org/10.1016/j.neuron.2015.09.002 (Any fulltext) Open Access status unknown

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Cao, Yan, Author
Sarria, Ignacio, Author
Fehlhaber, Katherine E., Author
Kamasawa, Naomi¹, Author
Orlandi, Cesare, Author
James, Kiely N., Author
Hazen, Jennifer L., Author
Gardner, Matthew R., Author
Farzan, Michael, Author
Lee, Amy, Author
Baker, Sheila, Author
Baldwin, Kristin, Author
Sampath, Alapakkam P., Author
Martemyanov, Kirill A., Author

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1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288

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Abstract: In the retina, rod and cone photoreceptors form distinct connections with different classes of downstream bipolar cells. However, the molecular mechanisms responsible for their selective connectivity are unknown. Here we identify a cell-adhesion protein, ELFN1, to be essential for the formation of synapses between rods and rod ON-bipolar cells in the primary rod pathway. ELFN1 is expressed selectively in rods where it is targeted to the axonal terminals by the synaptic release machinery. At the synapse, ELFN1 binds in trans to mGluR6, the postsynaptic receptor on rod ON-bipolar cells. Elimination of ELFN1 in mice prevents the formation of synaptic contacts involving rods, but not cones, allowing a dissection of the contributions of primary and secondary rod pathways to retinal circuit function and vision. We conclude that ELFN1 is necessary for the selective wiring of rods into the primary rod pathway and is required for high sensitivity of vision.

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Dates: Date issued: 2015-09-23

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Title: Neuron

Source Genre: Journal

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Pages: - Volume / Issue: 87 (6) Sequence Number: - Start / End Page: 1248 - 1260 Identifier: -