English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Functions of Rab proteins at presynaptic sites.

Binotti, B., Jahn, R., & Chua, J. J. E. (2016). Functions of Rab proteins at presynaptic sites. Cells, 5(1): 7. doi:10.3390/cells5010007.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-C7DE-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-924E-F
Genre: Journal Article

Files

show Files
hide Files
:
2253179.pdf (Publisher version), 641KB
Name:
2253179.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show
hide
Locator:
http://www.mdpi.com/2073-4409/5/1/7/pdf (Publisher version)
Description:
-

Creators

show
hide
 Creators:
Binotti, B.1, Author              
Jahn, R.1, Author              
Chua, J. J. E.2, Author              
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              
2Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society, ou_1933287              

Content

show
hide
Free keywords: Presynapse; synaptic transmission; small GTPases; Rabs; intracellular membrane trafficking; synaptic vesicle cycle; autophagy
 Abstract: Presynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles—a process involving bulk movement of membrane and proteins. As key mediators of membrane trafficking, small GTPases from the Rab family of proteins play critical roles in this process by acting as molecular switches that dynamically interact with and regulate the functions of different sets of macromolecular complexes involved in each stage of the cycle. Importantly, mutations affecting Rabs, and their regulators or effectors have now been identified that are implicated in severe neurological and neurodevelopmental disorders. Here, we summarize the roles and functions of presynaptic Rabs and discuss their involvement in the regulation of presynaptic function.

Details

show
hide
Language(s): eng - English
 Dates: 2016-02-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3390/cells5010007
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cells
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 10 Volume / Issue: 5 (1) Sequence Number: 7 Start / End Page: - Identifier: -