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  Functions of Rab proteins at presynaptic sites.

Binotti, B., Jahn, R., & Chua, J. J. E. (2016). Functions of Rab proteins at presynaptic sites. Cells, 5(1): 7. doi:10.3390/cells5010007.

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2253179.pdf (Publisher version), 641KB
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http://www.mdpi.com/2073-4409/5/1/7/pdf (Publisher version)
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 Creators:
Binotti, B.1, Author           
Jahn, R.1, Author           
Chua, J. J. E.2, Author           
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              
2Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society, ou_1933287              

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Free keywords: Presynapse; synaptic transmission; small GTPases; Rabs; intracellular membrane trafficking; synaptic vesicle cycle; autophagy
 Abstract: Presynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles—a process involving bulk movement of membrane and proteins. As key mediators of membrane trafficking, small GTPases from the Rab family of proteins play critical roles in this process by acting as molecular switches that dynamically interact with and regulate the functions of different sets of macromolecular complexes involved in each stage of the cycle. Importantly, mutations affecting Rabs, and their regulators or effectors have now been identified that are implicated in severe neurological and neurodevelopmental disorders. Here, we summarize the roles and functions of presynaptic Rabs and discuss their involvement in the regulation of presynaptic function.

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Language(s): eng - English
 Dates: 2016-02-06
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.3390/cells5010007
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Title: Cells
Source Genre: Journal
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Pages: 10 Volume / Issue: 5 (1) Sequence Number: 7 Start / End Page: - Identifier: -