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  A unified dynamic model for learning, replay, and sharp-wave/ripples

Jahnke, S., Timme, M., & Memmesheimer, R. M. (2015). A unified dynamic model for learning, replay, and sharp-wave/ripples. The Journal of Neuroscience, 35(49), 16236-16258. doi:10.1523/JNEUROSCI.3977-14.2015.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-D599-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-DFBF-D
Genre: Journal Article

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 Creators:
Jahnke, Sven1, Author              
Timme, Marc1, Author              
Memmesheimer, Raoul Martin2, Author              
Affiliations:
1Max Planck Research Group Network Dynamics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063295              
2Department of Nonlinear Dynamics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063286              

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Free keywords: and sleep,dendritic spikes,during phases of rest,generates intermittent patterns of,learning,memory,memory center,network,of the brain,replay,ripples,sharp-wave,significance statement,strongly increased overall activity,the,the hippocampus,the so-called sharp-wave,we investigate their,with high-frequency oscillations
 Abstract: Hippocampal activity is fundamental for episodic memory formation and consolidation. During phases of rest and sleep, it exhibits sharp-wave/ripple (SPW/R) complexes, which are short episodes of increased activity with superimposed high-frequency oscillations. Simultaneously, spike sequences reflecting previous behavior, such as traversed trajectories in space, are replayed. Whereas these phenomena are thought to be crucial for the formation and consolidation of episodic memory, their neurophysiological mechanisms are not well understood. Here we present a unified model showing how experience may be stored and thereafter replayed in association with SPW/Rs. We propose that replay and SPW/Rs are tightly interconnected as they mutually generate and support each other. The underlying mechanism is based on the nonlinear dendritic computation attributable to dendritic sodium spikes that have been prominently found in the hippocampal regions CA1 and CA3, where SPW/Rs and replay are also generated. Besides assigning SPW/Rs a crucial role for replay and thus memory processing, the proposed mechanism also explains their characteristic features, such as the oscillation frequency and the overall wave form. The results shed a new light on the dynamical aspects of hippocampal circuit learning.

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Language(s): eng - English
 Dates: 2015-12-092015-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.3977-14.2015
BibTex Citekey: Jahnke2015
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Title: The Journal of Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 35 (49) Sequence Number: - Start / End Page: 16236 - 16258 Identifier: ISSN: 0270-6474