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  tRNA wobble modifications and protein homeostasis.

Ranjan, N., & Rodnina, M. V. (2016). tRNA wobble modifications and protein homeostasis. Translation, 4(1): e1143076. doi:10.1080/21690731.2016.1143076.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-0548-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-0B9C-2
Genre: Journal Article

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2257677.pdf (Publisher version), 847KB
 
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 Creators:
Ranjan, N.1, Author              
Rodnina, M. V.1, Author              
Affiliations:
1Department of Physical Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578598              

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Free keywords: decoding, HIV-1, ribosomal frameshifting, ribosome profiling, tRNA modifications, translation regulation
 Abstract: tRNA is a central component of the protein synthesis machinery in the cell. In living cells, tRNAs undergo numerous post-transcriptional modifications. In particular, modifications at the anticodon loop play an important role in ensuring efficient protein synthesis, maintaining protein homeostasis, and helping cell adaptation and survival. Hypo-modification of the wobble position of the tRNA anticodon loop is of particular relevance for translation regulation and is implicated in various human diseases. In this review we summarize recent evidence of how methyl and thiol modifications in eukaryotic tRNA at position 34 affect cellular fitness and modulate regulatory circuits at normal conditions and under stress.

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Language(s): eng - English
 Dates: 2016-01-28
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1080/21690731.2016.1143076
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Title: Translation
Source Genre: Journal
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Pages: 11 Volume / Issue: 4 (1) Sequence Number: e1143076 Start / End Page: - Identifier: -