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  Amorfrutins Are Natural PPARgamma Agonists with Potent Anti-inflammatory Properties

Fuhr, L., Rousseau, M., Plauth, A., Schroeder, F. C., & Sauer, S. (2015). Amorfrutins Are Natural PPARgamma Agonists with Potent Anti-inflammatory Properties. Journal of Natural Products, 78(5), 1160-1164. doi:10.1021/np500747y.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-5FE9-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-5FEA-0
Genre: Journal Article

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© 2015 The American Chemical Society and American Society of Pharmacognosy
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http://www.ncbi.nlm.nih.gov/pubmed/25938459 (Any fulltext)
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 Creators:
Fuhr, Luise1, Author
Rousseau, Morten1, Author
Plauth, Annabell1, Author
Schroeder, Frank C.2, Author
Sauer, Sascha3, Author           
Affiliations:
1Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_persistent22              
2Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States, ou_persistent22              
3Nutrigenomics and Gene Regulation (Sascha Sauer), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479662              

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Free keywords: Anti-Inflammatory Agents/chemistry/*isolation & purification/*pharmacology Fabaceae/*chemistry Glycyrrhiza/metabolism Molecular Structure PPAR gamma/*agonists Receptors, Cytoplasmic and Nuclear/metabolism Salicylates/chemistry/*isolation & purification/*pharmacology Stilbenes/chemistry/*isolation & purification/*pharmacology Tumor Necrosis Factor-alpha/pharmacology
 Abstract: Amorfrutins are isoprenoid-substituted benzoic acid derivatives, which were found in Amorpha fruticosa L. (bastard indigo) and in Glycyrrhiza foetida Desf. (licorice). Recently, amorfrutins were shown to be selective activators of the nuclear receptor PPARgamma. Here, we investigated the effects and PPARgamma-based mechanisms of reducing inflammation in colon cells by treatment with amorfrutins. In TNF-alpha-stimulated colon cells amorfrutin A (1) reduced significantly the expression and secretion of several inflammation mediators, in part due to interaction with PPARgamma. These results support the hypothesis that amorfrutins may have the potential to treat inflammation disorders such as chronic inflammatory bowel diseases.

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Language(s): eng - English
 Dates: 2015-05-042015-05-22
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1021/np500747y
ISSN: 1520-6025 (Electronic)0163-3864 (Print)
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Title: Journal of Natural Products
  Other : J. Nat. Prod.
Source Genre: Journal
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Publ. Info: Cincinnati, Ohio : American Society of Pharmacognosy.
Pages: - Volume / Issue: 78 (5) Sequence Number: - Start / End Page: 1160 - 1164 Identifier: ISSN: 0163-3864
CoNE: https://pure.mpg.de/cone/journals/resource/954927550329