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  PRMT1-mediated arginine methylation controls ATXN2L localization

Kähler, C., Guenther, A., Uhlich, A., & Krobitsch, S. (2015). PRMT1-mediated arginine methylation controls ATXN2L localization. Experimental Cell Research, 334(1), 114-125. doi:10.1016/j.yexcr.2015.02.022.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-5FD2-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-5FD3-2
Genre: Journal Article

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© 2015 Elsevier Inc.
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 Creators:
Kähler, Christian1, Author              
Guenther, Anika1, Author
Uhlich, Anja1, Author
Krobitsch, Sylvia1, Author              
Affiliations:
1Neurodegenerative Disorders (Sylvia Krobitsch), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479661              

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Free keywords: Arginine/*metabolism HeLa Cells Humans Methylation Nerve Tissue Proteins/*metabolism Protein Transport Protein-Arginine N-Methyltransferases/*metabolism Repressor Proteins/*metabolism Tumor Cells, Cultured Asymmetric arginine dimethylation Ataxin-2-like Protein arginine methyltransferase Splicing speckles Stress granules
 Abstract: Arginine methylation is a posttranslational modification that is of importance in diverse cellular processes. Recent proteomic mass spectrometry studies reported arginine methylation of ataxin-2-like (ATXN2L), the paralog of ataxin-2, a protein that is implicated in the neurodegenerative disorder spinocerebellar ataxia type 2. Here, we investigated the methylation state of ATXN2L and its significance for ATXN2L localization. We first confirmed that ATXN2L is asymmetrically dimethylated in vivo, and observed that the nuclear localization of ATXN2L is altered under methylation inhibition. We further discovered that ATXN2L associates with the protein arginine-N-methyltransferase 1 (PRMT1). Finally, we showed that neither mutation of the arginine-glycine-rich motifs of ATXN2L nor methylation inhibition alters ATXN2L localization to stress granules, suggesting that methylation of ATXN2L is probably not mandatory.

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Language(s): eng - English
 Dates: 2015-03-052015-05-15
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.yexcr.2015.02.022
ISSN: 1090-2422 (Electronic)0014-4827 (Print)
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Title: Experimental Cell Research
  Other : Exp. Cell Res.
Source Genre: Journal
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Publ. Info: San Diego, CA : Academic Press
Pages: - Volume / Issue: 334 (1) Sequence Number: - Start / End Page: 114 - 125 Identifier: ISSN: 0014-4827
CoNE: https://pure.mpg.de/cone/journals/resource/954922645016