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  Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

Pajtler, K. W., Witt, H., Sill, M., Jones, D. T., Hovestadt, V., Kratochwil, F., et al. (2015). Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. Cancer Cell, 27(5), 728-743. doi:10.1016/j.ccell.2015.04.002.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-58F0-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-58F3-3
Genre: Journal Article

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 Creators:
Pajtler, K. W., Author
Witt, H., Author
Sill, M., Author
Jones, D. T., Author
Hovestadt, V., Author
Kratochwil, F., Author
Wani, K., Author
Tatevossian, R., Author
Punchihewa, C., Author
Johann, P., Author
Reimand, J., Author
Warnatz, H.-J.1, Author              
Ryzhova, M., Author
Mack, S., Author
Ramaswamy, V., Author
Capper, D., Author
Schweizer, L., Author
Sieber, L., Author
Wittmann, A., Author
Huang, Z., Author
van Sluis, P., AuthorVolckmann, R., AuthorKoster, J., AuthorVersteeg, R., AuthorFults, D., AuthorToledano, H., AuthorAvigad, S., AuthorHoffman, L. M., AuthorDonson, A. M., AuthorForeman, N., AuthorHewer, E., AuthorZitterbart, K., AuthorGilbert, M., AuthorArmstrong, T. S., AuthorGupta, N., AuthorAllen, J. C., AuthorKarajannis, M. A., AuthorZagzag, D., AuthorHasselblatt, M., AuthorKulozik, A. E., AuthorWitt, O., AuthorCollins, V. P., Authorvon Hoff, K., AuthorRutkowski, S., AuthorPietsch, T., AuthorBader, G., AuthorYaspo, M. L.1, Author              von Deimling, A., AuthorLichter, P., AuthorTaylor, M. D., AuthorGilbertson, R., AuthorEllison, D. W., AuthorAldape, K., AuthorKorshunov, A., AuthorKool, M., AuthorPfister, S. M., Author more..
Affiliations:
1Gene Regulation and Systems Biology of Cancer (Marie-Laure Yaspo), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117287              

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Free keywords: Adaptor Proteins, Signal Transducing/genetics Adolescent Adult *Age Factors Aged Central Nervous System Neoplasms/classification/genetics/*pathology Child Child, Preschool DNA Methylation Ependymoma/classification/genetics/*pathology Female Gene Dosage Gene Expression Profiling Gene Fusion Humans Infant Male Middle Aged Phosphoproteins/genetics Transcription, Genetic Young Adult
 Abstract: Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.

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Language(s): eng - English
 Dates: 2015-05-11
 Publication Status: Published in print
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.ccell.2015.04.002
ISSN: 1878-3686 (Electronic)1535-6108 (Print)
 Degree: -

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Title: Cancer Cell
  Other : Cancer Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 27 (5) Sequence Number: - Start / End Page: 728 - 743 Identifier: ISSN: 1535-6108
CoNE: https://pure.mpg.de/cone/journals/resource/111025129473004