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  Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma

Sauer, S. (2015). Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma. Trends in Pharmacological Sciences, 36(10), 688-704. doi:10.1016/j.tips.2015.06.010.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-58C6-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-58C7-9
Genre: Journal Article

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Sauer.pdf (Publisher version), 4MB
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© 2015 Elsevier Ltd
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 Creators:
Sauer, Sascha1, Author              
Affiliations:
1Nutrigenomics and Gene Regulation (Sascha Sauer), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479662              

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 Abstract: Nuclear receptors are ligand-activated transcription factors, which represent a primary class of drug targets. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is a key player in various biological processes. PPARgamma is widely known as the target protein of the thiazolidinediones for treating type 2 diabetes. Moreover, PPARgamma ligands can induce anti-inflammatory and potentially additional beneficial effects. Recent mechanistic insights of PPARgamma modulation give hope the next generation of efficient PPARgamma-based drugs with fewer side effects can be developed. Furthermore, chemical approaches that make use of synergistic action of combinatorial ligands are promising alternatives for providing tailored medicine. Lessons learned from fine-tuning the action of PPARgamma can provide avenues for efficient molecular intervention via many other nuclear receptors to combat common diseases.

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Language(s): eng - English
 Dates: 2015-10
 Publication Status: Published in print
 Pages: 17
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.tips.2015.06.010
ISSN: 1873-3735 (Electronic)0165-6147 (Print)
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Title: Trends in Pharmacological Sciences
Source Genre: Journal
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Publ. Info: Cambridge, UK : Elsevier Current Trends
Pages: - Volume / Issue: 36 (10) Sequence Number: - Start / End Page: 688 - 704 Identifier: ISSN: 0165-6147
CoNE: https://pure.mpg.de/cone/journals/resource/954925481621