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  Evolutionary rescue from extinction is contingent on a lower rate of environmental change

Lindsey, H. A., Gallie, J., Taylor, S., & Kerr, B. (2013). Evolutionary rescue from extinction is contingent on a lower rate of environmental change. Nature, 494: nature11879, pp. 463-467. doi:10.1038/nature11879.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-07AE-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-07AF-0
Genre: Journal Article

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 Creators:
Lindsey, Haley A., Author
Gallie, Jenna1, Author              
Taylor, Susan, Author
Kerr, Benjamin, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Experimental evolution; evolutionary biology; evolutionary genetics
 Abstract: The extinction rate of populations is predicted to rise under increasing rates of environmental change1, 2, 3. If a population experiencing increasingly stressful conditions lacks appropriate phenotypic plasticity or access to more suitable habitats, then genetic change may be the only way to avoid extinction1. Evolutionary rescue from extinction occurs when natural selection enriches a population for more stress-tolerant genetic variants1, 3. Some experimental studies have shown that lower rates of environmental change lead to more adapted populations or fewer extinctions4, 5, 6, 7, 8, 9. However, there has been little focus on the genetic changes that underlie evolutionary rescue. Here we demonstrate that some evolutionary trajectories are contingent on a lower rate of environmental change. We allowed hundreds of populations of Escherichia coli to evolve under variable rates of increase in concentration of the antibiotic rifampicin. We then genetically engineered all combinations of mutations from isolates evolved under lower rates of environmental change. By assessing fitness of these engineered strains across a range of drug concentrations, we show that certain genotypes are evolutionarily inaccessible under rapid environmental change. Rapidly deteriorating environments not only limit mutational opportunities by lowering population size, but they can also eliminate sets of mutations as evolutionary options. As anthropogenic activities are leading to environmental change at unprecedented rapidity1, it is critical to understand how the rate of environmental change affects both demographic and genetic underpinnings of evolutionary rescue.

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Language(s): eng - English
 Dates: 2012-09-142012-12-212016-02-102013-02-28
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/nature11879
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 494 Sequence Number: nature11879 Start / End Page: 463 - 467 Identifier: ISSN: 0028-0836
CoNE: /journals/resource/954925427238