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  Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Franke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., Van Hulzen, K. J. E., et al. (2016). Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience, 19, 420-431. doi:10.1038/nn.4228.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-0967-F Version Permalink: https://hdl.handle.net/21.11116/0000-0003-4A2A-C
Genre: Journal Article

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 Creators:
Franke, Barbara1, 2, Author
Stein, Jason L.3, 4, Author
Ripke, Stephan5, 6, 7, Author
Anttila, Verneri5, 6, Author
Hibar, Derrek P.3, Author
Van Hulzen, Kimm J. E.1, 8, Author
Arias-Vasquez, Alejandro1, 8, Author
Smoller, Jordan W.5, 6, 9, Author
Nichols, Thomas E.10, 11, Author
Neale, Michael C.12, Author
McIntosh, Andrew M.13, Author
Lee, Phil5, 6, 9, Author
McMahon, Francis J.14, Author
Meyer-Lindenberg, Andreas15, Author
Mattheisen, Manuel16, 17, Author
Andreassen, Ole A.18, 19, Author
Gruber, Oliver20, Author
Sachdev, Perminder S.21, 22, Author
Roiz-Santiañez, Roberto23, 24, Author
Saykin, Andrew J.25, Author
more..
Affiliations:
1Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
2University of Pittsburgh, Pittsburgh, PA, USA, ou_persistent22              
3Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA, ou_persistent22              
4University of California Los Angeles, Los Angeles, CA, USA, ou_persistent22              
5Massachusetts General Hospital, Boston, MA, USA, ou_persistent22              
6Broad Institute of MIT and Harvard, Cambridge, MA, USA, ou_persistent22              
7Charité Universitätsmedizin Berlin, Berlin, Germany, ou_persistent22              
8Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
9Harvard Medical School, Boston, MA, USA, ou_persistent22              
10University of Oxford, Oxford, UK, ou_persistent22              
11University of Warwick, Coventry, UK, ou_persistent22              
12Virginia Commonwealth University, Richmond, VA, USA, ou_persistent22              
13University of Edinburgh, Edinburgh, UK, ou_persistent22              
14National Institute of Mental Health, Bethesda, MD, USA, ou_persistent22              
15University Heidelberg, Mannheim, Germany, ou_persistent22              
16Aarhus University, Aarhus, Denmark, ou_persistent22              
17Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, ou_persistent22              
18University of Oslo, Oslo, Norway, ou_persistent22              
19Oslo University Hospital, Oslo, Norway, ou_persistent22              
20University Medical Center Goettingen, Goettingen, Germany, ou_persistent22              
21University of New South Wales, Sydney, Australia, ou_persistent22              
22Prince of Wales Hospital, Sydney, Australia, ou_persistent22              
23University of Cantabria-IDIVAL, Santander, Spain, ou_persistent22              
24Cibersam (Centro Investigación Biomédica en Red Salud Mental), Madrid, Spain, ou_persistent22              
25Indiana University School of Medicine, Indianapolis, IN, USA, ou_persistent22              
26Dresden University of Technology, Dresden, Germany, ou_persistent22              
27Georgia State University, Atlanta, GA, USA, ou_persistent22              
28Mind Research Network, Albuquerque, NM, USA, ou_persistent22              
29QIMR Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
30University of Queensland, Brisbane, Australia, ou_persistent22              
31Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
32Imaging Genomics, MPI for Psycholinguistics, Max Planck Society, Wundtlaan 1, 6525 XD Nijmegen, NL, ou_2579692              
33Cardiff University, Cardiff, UK, ou_persistent22              
34Karolinska Institutet, Stockholm, Sweden, ou_persistent22              
35University of North Carolina, Chapel Hill, NC, USA, ou_persistent22              

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 Abstract: Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders

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Language(s): eng - English
 Dates: 2016
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nn.4228
 Degree: -

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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
 Creator(s):
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 19 Sequence Number: - Start / End Page: 420 - 431 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931