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  The roles of microtubule-based transport at presynaptic nerve terminals.

Yagensky, O., Kalantary Dehaghi, T., & Chua, J. J. E. (2016). The roles of microtubule-based transport at presynaptic nerve terminals. Frontiers in Synaptic Neuroscience, 8: 3. doi:10.3389/fnsyn.2016.00003.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-0AB1-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-296E-9
Genre: Journal Article

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2259598.pdf (Publisher version), 411KB
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 Creators:
Yagensky, O.1, Author              
Kalantary Dehaghi, T.1, Author              
Chua, J. J. E.1, Author              
Affiliations:
1Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society, ou_1933287              

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Free keywords: Presynapse; Intracellular trafficking; Kinesin; Dynein; Signaling pathways; Synaptogenesis; Autophagy
 Abstract: Targeted intracellular movement of presynaptic proteins plays important roles during synapse formation and, later, in the homeostatic maintenance of mature synapses. Movement of these proteins, often as vesicular packages, is mediated by motor complexes travelling along intracellular cytoskeletal networks. Presynaptic protein transport by kinesin motors in particular plays important roles during synaptogenesis to bring newly synthesized proteins to establish nascent synaptic sites. Conversely, movement of proteins away from presynaptic sites by Dynein motors enables synapsenuclear signaling and allows for synaptic renewal through degradation of unwanted or damaged proteins. Remarkably, recent data has indicated that synaptic and protein trafficking machineries can modulate each other’s functions. Here, we survey the mechanisms involved in moving presynaptic components to and away from synapses and how this process supports presynaptic function.

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Language(s): eng - English
 Dates: 2016-02-10
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnsyn.2016.00003
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Title: Frontiers in Synaptic Neuroscience
Source Genre: Journal
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Pages: 9 Volume / Issue: 8 Sequence Number: 3 Start / End Page: - Identifier: -