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  Validating new diagnostic imaging criteria for primary progressive aphasia via anatomical likelihood estimation meta-analyses

Bisenius, S., Neumann, J., & Schroeter, M. L. (2016). Validating new diagnostic imaging criteria for primary progressive aphasia via anatomical likelihood estimation meta-analyses. European Journal of Neurology, 23(4), 704-712. doi:10.1111/ene.12902.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-1098-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1DCA-A
Genre: Journal Article

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 Creators:
Bisenius, Sandrine1, Author              
Neumann, Jane1, 2, Author              
Schroeter, Matthias L.1, 3, 4, 5, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Consortium for Frontotemporal Lobar Degeneration, Leipzig, Germany, ou_persistent22              

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Free keywords: Logopenic progressive aphasia; Meta-analysis; Primary progressive aphasia; Progressive nonfluent aphasia; Semantic dementia
 Abstract: Recently, diagnostic clinical and imaging criteria for primary progressive aphasia (PPA) have been revised by an international consortium (Gorno-Tempini et al. Neurology 2011;76:1006-14). The aim of this study was to validate the specificity of the new imaging criteria and investigate whether different imaging modalities [magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET)] require different diagnostic subtype-specific imaging criteria. Anatomical likelihood estimation meta-analyses were conducted for PPA subtypes across a large cohort of 396 patients: firstly, across MRI studies for each of the three PPA subtypes followed by conjunction and subtraction analyses to investigate the specificity, and, secondly, by comparing results across MRI vs. FDG-PET studies in semantic dementia and progressive nonfluent aphasia. Semantic dementia showed atrophy in temporal, fusiform, parahippocampal gyri, hippocampus, and amygdala, progressive nonfluent aphasia in left putamen, insula, middle/superior temporal, precentral, and frontal gyri, logopenic progressive aphasia in middle/superior temporal, supramarginal, and dorsal posterior cingulate gyri. Results of the disease-specific meta-analyses across MRI studies were disjunct. Similarly, atrophic and hypometabolic brain networks were regionally dissociated in both semantic dementia and progressive nonfluent aphasia. In conclusion, meta-analyses support the specificity of new diagnostic imaging criteria for PPA and suggest that they should be specified for each imaging modality separately.

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Language(s): eng - English
 Dates: 2015-06-222015-10-012016-02-222016-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1111/ene.12902
PMID: 26901360
Other: Epub 2016
 Degree: -

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Title: European Journal of Neurology
  Other : Eur. J. Neurol.
Source Genre: Journal
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Pages: - Volume / Issue: 23 (4) Sequence Number: - Start / End Page: 704 - 712 Identifier: ISSN: 1351-5101
CoNE: /journals/resource/954925617087