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  NompC TRP channel required for vertebrate sensory hair cell mechanotransduction

Sidi, S., Friedrich, R. W., & Nicolson, T. (2003). NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science, 301(5629), 96-99. doi:10.1126/science.1084370.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-114C-E Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-114D-C
Genre: Journal Article
Alternative Title : NompC TRP channel required for vertebrate sensory hair cell mechanotransduction

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Science_301_2003_96.pdf (Any fulltext), 338KB
 
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Sidi, Samuel, Author
Friedrich, Rainer W.1, Author           
Nicolson, Teresa, Author
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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 Abstract: The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.

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Language(s): eng - English
 Dates: 2003-03-112003-06-062003-06-122003-07-04
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665846
DOI: 10.1126/science.1084370
URI: http://www.ncbi.nlm.nih.gov/pubmed/12805553
URI: http://science.sciencemag.org/content/301/5629/96
URI: http://science.sciencemag.org/content/301/5629/96.full
Other: 6034
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 301 (5629) Sequence Number: - Start / End Page: 96 - 99 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1