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  High-probability uniquantal transmission at excitatory synapses in barrel cortex

Silver, R. A., Lübke, J. H. R., Sakmann, B., & Feldmeyer, D. (2003). High-probability uniquantal transmission at excitatory synapses in barrel cortex. Science, 302(5652), 1981-1984. doi:10.1126/science.1087160.

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Genre: Journal Article
Alternative Title : High-probability uniquantal transmission at excitatory synapses in barrel cortex

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Science_302_2003_1981.pdf (Any fulltext), 1021KB
 
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Silver, R. Angus, Author
Lübke, Joachim H. R., Author
Sakmann, Bert1, Author           
Feldmeyer, Dirk1, Author           
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: The number of vesicles released at excitatory synapses and the number of release sites per synaptic connection are key determinants of information processing in the cortex, yet they remain uncertain. Here we show that the number of functional release sites and the number of anatomically identified synaptic contacts are equal at connections between spiny stellate and pyramidal cells in rat barrel cortex. Moreover, our results indicate that the amount of transmitter released per synaptic contact is independent of release probability and the intrinsic release probability is high. These properties suggest that connections between layer 4 and layer 2/3 are tuned for reliable transmission of spatially distributed, timing-based signals.

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Language(s): eng - English
 Dates: 2003-05-232003-10-152003-12-12
 Publication Status: Published in print
 Pages: 4
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 Rev. Type: Peer
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 302 (5652) Sequence Number: - Start / End Page: 1981 - 1984 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1