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  zag-1, a Zn-finger homeodomain transcription factor controlling neuronal differentiation and axon outgrowth in C. elegans

Wacker-Schröder, I., Schwarz, V., Hedgecock, E. M., & Hutter, H. (2003). zag-1, a Zn-finger homeodomain transcription factor controlling neuronal differentiation and axon outgrowth in C. elegans. Development, 130(16), 3795-3805. doi:10.1242/dev.00570.

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Genre: Journal Article
Alternative Title : zag-1, a Zn-finger homeodomain transcription factor controlling neuronal differentiation and axon outgrowth in C. elegans

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 Creators:
Wacker-Schröder, Irene1, Author              
Schwarz, Valentin2, Author              
Hedgecock, Edward M., Author
Hutter, Harald2, Author              
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              
2Max Planck Research Group Developmental Genetics of the nervous system (Harald Hutter), Max Planck Institute for Medical Research, Max Planck Society, ou_1497723              

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Free keywords: zag-1, C. elegans, Neuronal differentiation, Axon guidance
 Abstract: The nervous system consists of diverse subtypes of neurons, whose identities must be specified during development. One important aspect of the differentiation program of neurons is the expression of the appropriate set of genes controlling axon pathway selection. We have identified a novel Znfinger/homeodomain containing transcription factor, zag-1, required for particular aspects of axonal pathfinding. In zag-1 mutants, motorneuron commissures either branch prematurely or fail to branch at the correct point. Ventral cord interneurons show defects in the guidance towards the ventral cord and also in the ventral cord. Several neurons misexpress differentiation markers, including glutamate receptor subunits and chemosensory receptors. zag-1 is expressed transiently in embryonic and postembryonic neurons during differentiation as well as in some mesodermal tissues. Null mutants of zag-1 are unable to swallow food and die as L1 larvae with a starved appearance, indicating that zag-1 has an additional role in pharynx development. The vertebrate homolog, deltaEF1, is highly conserved and known to act as transcriptional repressor in various tissues. Our data indicate that zag-1 also acts as transcriptional repressor controlling important aspects of terminal differentiation of neurons.

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Language(s): eng - English
 Dates: 2003-05-012003-08-01
 Publication Status: Published in print
 Pages: 11
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 Table of Contents: -
 Rev. Type: Peer
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Title: Development
  Other : Development
Source Genre: Journal
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Publ. Info: Cambridge, Cambridgeshire : Company of Biologists
Pages: - Volume / Issue: 130 (16) Sequence Number: - Start / End Page: 3795 - 3805 Identifier: ISSN: 0950-1991
CoNE: https://pure.mpg.de/cone/journals/resource/954927546241