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  Supralinear Ca2+ influx into dendritic tufts of layer 2/3 neocortical pyramidal neurons in vitro and in vivo

Waters, D. J., Larkum, M. E., Sakmann, B., & Helmchen, F. (2003). Supralinear Ca2+ influx into dendritic tufts of layer 2/3 neocortical pyramidal neurons in vitro and in vivo. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 23(24), 8558-8567. Retrieved from http://www.jneurosci.org/cgi/content/abstract/23/24/8558?maxtoshow%3D%26HITS%3D10%26hits%3D10%26RESULTFORMAT%3D1%26andorexacttitle%3Dand%26andorexacttitleabs%3Dand%26andorexactfulltext%3Dand%26searchid%3D1083074896258_4246%26stored_search%3D%26FIRSTINDEX%3D0%26sortspec%3Drelevance%26volume%3D23%26first.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-122B-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-122C-E
Genre: Journal Article
Alternative Title : Supralinear Ca2+ influx into dendritic tufts of layer 2/3 neocortical pyramidal neurons in vitro and in vivo

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JNeurosci_23_2003_8558.pdf (Any fulltext), 453KB
 
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 Creators:
Waters, David Jack1, Author              
Larkum, Matthew E.1, Author              
Sakmann, Bert1, Author              
Helmchen, Fritjof1, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: neocortex; dendrite; two-photon; calcium; layer 2/3; backpropagation
 Abstract: Pyramidal neurons in layer 2/3 of the neocortex are central to cortical circuitry, but the intrinsic properties of their dendrites are poorly understood. Here we study layer 2/3 apical dendrites in parallel experiments in acute brain slices and in anesthetized rats using whole-cell recordings and Ca2+ imaging. We find that backpropagation of action potentials into the dendritic arbor is actively supported by Na+ channels both in vitro and in vivo. Single action potentials evoke substantial Ca2+ influx in the apical trunk but little or none in the dendritic tuft. Supralinear Ca2+ influx is produced in the tuft, however, when an action potential is paired with synaptic input. This dendritic supralinearity enables layer 2/3 neurons to integrate ascending sensory input from layer 4 and associative input to layer 1.

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Language(s): eng - English
 Dates: 2003-07-152003-06-072003-07-152003-09-17
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 23 (24) Sequence Number: - Start / End Page: 8558 - 8567 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1