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  Self-assembly of lipid domains in the extracellular leaflet of the plasma membrane and models thereof

Andersson Trojer, M., & Brezesinski, G. (2016). Self-assembly of lipid domains in the extracellular leaflet of the plasma membrane and models thereof. Current Opinion in Colloid & Interface Science, 22, 65-72. doi:10.1016/j.cocis.2016.03.001.

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 Creators:
Andersson Trojer, Markus1, Author              
Brezesinski, Gerald1, Author              
Affiliations:
1Gerald Brezesinski, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863500              

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Free keywords: Phase diagram; liquid ordered; lipid raft; Langmuir monolayer; ganglioside; IRRAS; line tension; avidity
 Abstract: Lipid domain formation and phase coexistence in biological membranes is a subject which has received considerable attention during the last two decades. Especially the topic concerning so-called lipid rafts, a theory which has become as popular to confirm as to disproof. Regardless of the existence or precise composition and function of the classical rafts, the occurrence of lateral lipid segregation in biological membranes is indisputable. This review starts by focusing on state of the art findings concerning lipid domains and lateral heterogeneity in a biological context. Then, the physicochemical properties of lipid mixtures, phase properties and domain dynamics are considered. Canonical lipid models of the exofacial leaflet of the plasma membrane are treated in detail and the proper choices of model lipids are discussed. A special attention is given to polar lateral interactions (including carbohydrate-carbohydrate head group interactions), whose importance for spatial segregation and crystallization is commencing to be appreciated by the scientific community.

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 Dates: 2016-03-192016
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.cocis.2016.03.001
BibTex Citekey: Trojer2016
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Title: Current Opinion in Colloid & Interface Science
  Other : Curr. Opin. Colloid Interface Sci.
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 22 Sequence Number: - Start / End Page: 65 - 72 Identifier: ISSN: 1359-0294