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  Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice.

Abraham, N. M., Spors, H., Carleton, A., Margrie, T. W., Kuner, T., & Schaefer, A. T. (2004). Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice. Neuron, 44(5), 865-876. doi:10.1016/j.neuron.2004.11.017.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-14B2-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-14B3-C
Genre: Journal Article
Alternative Title : Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice.

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Neuron_44_2004_865.pdf (Any fulltext), 612KB
 
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 Creators:
Abraham, Nixon M.1, Author              
Spors, Hartwig1, Author              
Carleton, Alan1, Author              
Margrie, Troy W.1, 2, Author              
Kuner, Thomas1, 2, Author              
Schaefer, Andreas T.1, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Odor discrimination times and their dependence on stimulus similarity were evaluated to test temporal and spatial models of odor representation in mice. In a go/no-go operant conditioning paradigm, discrimination accuracy and time were determined for simple monomolecular odors and binary mixtures of odors. Mice discriminated simple odors with an accuracy exceeding 95%. Binary mixtures evoking highly overlapping spatiotemporal patterns of activity in the olfactory bulb were discriminated equally well. However, while discriminating simple odors in less than 200 ms, mice required 70-100 ms more time to discriminate highly similar binary mixtures. We conclude that odor discrimination in mice is fast and stimulus dependent. Thus, the underlying neuronal mechanisms act on a fast timescale, requiring only a brief epoch of odor-specific spatiotemporal representations to achieve rapid discrimination of dissimilar odors. The fine discrimination of highly similar stimuli, however, requires temporal integration of activity, suggesting a tradeoff between accuracy and speed.

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Language(s): eng - English
 Dates: 2004-05-142004-11-082004-12-012004-12-02
 Publication Status: Published in print
 Pages: 12
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 Table of Contents: -
 Rev. Method: Peer
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 44 (5) Sequence Number: - Start / End Page: 865 - 876 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565