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  Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity.

Dreyer, J., Schleicher, M., Tappe-Theodor, A., Schilling, K., Kuner, T., Kusumawidijaja, G., et al. (2004). Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 24(46), 10454-10465. doi:10.1523/JNEUROSCI.2265-04.2004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-15E7-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-15E8-0
Genre: Journal Article
Alternative Title : Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity.

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 Creators:
Dreyer, Jacqueline, Author
Schleicher, Michael, Author
Tappe-Theodor, Anke, Author
Schilling, Kirstin, Author
Kuner, Thomas1, 2, Author              
Kusumawidijaja, Grace, Author
Müller-Esterl, Werner, Author
Oess, Stefanie, Author
Kuner, Rohini, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: nitric oxide; synaptic spines; hippocampal neurons; protein-protein interactions; seizures; inflammatory pain
 Abstract: Mechanisms governing the activity of neuronal nitric oxide synthase (nNOS), the major source of nitric oxide (NO) in the nervous system, are not completely understood. We report here a protein-protein interaction between nNOS and NOSIP (nitric oxide synthase-interacting protein) in rat brain in vivo. NOSIP and nNOS are concentrated in neuronal synapses and demonstrate significant colocalization in various regions of the central and peripheral nervous systems. NOSIP produces a significant reduction in nNOS activity in a neuroepithelioma cell line stably expressing nNOS. Furthermore, overexpression of NOSIP in cultured primary neurons reduces the availability of nNOS in terminal dendrites. These results thus suggest that the interaction between NOSIP and nNOS is functionally involved in endogenous mechanisms regulating NO synthesis. Furthermore, we found that the subcellular distribution and expression levels of NOSIP are dynamically regulated by neuronal activity in vitro as well as in vivo, suggesting that NOSIP may contribute to a mechanism via which neuronal activity regulates the synaptic availability and activity of nNOS.

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Language(s): eng - English
 Dates: 2004-10-072004-06-092004-10-072004-11-17
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 24 (46) Sequence Number: - Start / End Page: 10454 - 10465 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1