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  Mechanisms of Glucocorticoid-Regulated Gene Transcription

Meijsing, S. H. (2015). Mechanisms of Glucocorticoid-Regulated Gene Transcription. In J.-C. Wang, & C. Harris (Eds.), Glucocorticoid Signaling: From Molecules to Mice to Man.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-3A97-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-3A98-5
Genre: Book Chapter

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Meijsing.pdf (Publisher version), 803KB
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© Springer Science+Business Media New York 2015
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 Creators:
Meijsing, Sebastiaan H.1, Author              
Affiliations:
1Mechanisms of Transcriptional Regulation (Sebastiaan H. Meijsing), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479641              

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Free keywords: Animals Gene Expression Regulation/*physiology Glucocorticoids/*physiology Humans Protein Processing, Post-Translational Receptors, Glucocorticoid/metabolism Transcription, Genetic/*physiology
 Abstract: One fascinating aspect of glucocorticoid signaling is their broad range of physiological and pharmacological effects. These effects are at least in part a consequence of transcriptional regulation by the glucocorticoid receptor (GR). Activation of GR by glucocorticoids results in tissue-specific changes in gene expression levels with some genes being activated whereas others are repressed. This raises two questions: First, how does GR regulate different subsets of target genes in different tissues? And second, how can GR both activate and repress the expression of genes?To answer these questions, this chapter will describe the function of the various "components" and how they cooperate to mediate the transcriptional responses to glucocorticoids. The first "component" is GR itself. The second "component" is the chromatin and its role in specifying where in the genome GR binds. Binding to the genome however is just the first step in regulating the expression of genes and transcriptional regulation by GR depends on the recruitment of coregulator proteins that either directly or indirectly influence the recruitment and or activity of RNA polymerase II. Ultimately, the integration of inputs including GR isoform, DNA sequence, chromatin and cooperation with coregulators determines which genes are regulated and the direction of their regulation.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 23
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/978-1-4939-2895-8_3
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Source 1

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Title: Glucocorticoid Signaling : From Molecules to Mice to Man
Source Genre: Book
 Creator(s):
Wang, Jen-Chywan , Editor
Harris , Charles, Editor
Affiliations:
-
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISBN: 978-1-4939-2894-1 (Print) 978-1-4939-2895-8 (Online)

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Title: Advances in Experimental Medicine and Biology
Source Genre: Series
 Creator(s):
Cohen, Irun R., Editor
Lajtha, Abel, Editor
Lambris, John D., Editor
Affiliations:
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Publ. Info: Springer Science+Business Media
Pages: - Volume / Issue: 872 Sequence Number: - Start / End Page: 59 - 81 Identifier: ISSN: 0065-2598 (print) 2214-8019 (online)