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  Evidence of Extrapancreatic Glucagon Secretion in Man

Lund, A., Bagger, J. I., Albrechtsen, N. J. W., Christensen, M., Grondahl, M., Hartmann, B., et al. (2016). Evidence of Extrapancreatic Glucagon Secretion in Man. DIABETES, 65(3), 585-597. doi:10.2337/db15-1541.

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 Creators:
Lund, Asger1, Author
Bagger, Jonatan I.1, Author
Albrechtsen, Nicolai J. Wewer2, Author              
Christensen, Mikkel1, Author
Grondahl, Magnus1, Author
Hartmann, Bolette1, Author
Mathiesen, Elisabeth R.1, Author
Hansen, Carsten P.1, Author
Storkholm, Jan H.1, Author
van Hall, Gerrit1, Author
Rehfeld, Jens F.1, Author
Hornburg, Daniel1, Author
Meissner, Felix2, 3, Author              
Mann, Matthias2, Author              
Larsen, Steen1, Author
Holst, Jens J.1, Author
Vilsboll, Tina1, Author
Knop, Filip K.1, Author
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
3Meissner, Felix / Experimental Systems Immunology, Max Planck Institute of Biochemistry, Max Planck Society, ou_2149678              

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Free keywords: ALPHA-CELL HYPERPLASIA; Y GASTRIC BYPASS; TOTAL PANCREATECTOMY; DEPANCREATIZED DOGS; IMMUNOREACTIVE GLUCAGON; ORAL GLUCOSE; HUMANS; RECEPTOR; PANCREAS; PLASMA
 Abstract: Glucagon is believed to be a pancreas-specific hormone, and hyperglucagonemia has been shown to contribute significantly to the hyperglycemic state of patients with diabetes. This hyperglucagonemia has been thought to arise from -cell insensitivity to suppressive effects of glucose and insulin combined with reduced insulin secretion. We hypothesized that postabsorptive hyperglucagonemia represents a gut-dependent phenomenon and subjected 10 totally pancreatectomized patients and 10 healthy control subjects to a 75-g oral glucose tolerance test and a corresponding isoglycemic intravenous glucose infusion. We applied novel analytical methods of plasma glucagon (sandwich ELISA and mass spectrometry-based proteomics) and show that 29-amino acid glucagon circulates in patients without a pancreas and that glucose stimulation of the gastrointestinal tract elicits significant hyperglucagonemia in these patients. These findings emphasize the existence of extrapancreatic glucagon (perhaps originating from the gut) in man and suggest that it may play a role in diabetes secondary to total pancreatectomy.

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Language(s): eng - English
 Dates: 2015-12-152016
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000370961000014
DOI: 10.2337/db15-1541
 Degree: -

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Title: DIABETES
Source Genre: Journal
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Publ. Info: 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA : AMER DIABETES ASSOC
Pages: - Volume / Issue: 65 (3) Sequence Number: - Start / End Page: 585 - 597 Identifier: ISSN: 0012-1797